MLS1547
- Product Name
- MLS1547
- CAS No.
- 315698-36-3
- Chemical Name
- MLS1547
- Synonyms
- MLS1547;MLS000051547;MLS1547[SML1331];MLS1547 >=98% (HPLC);MLS1547, 10 mM in DMSO;5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol;8-Quinolinol, 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-;Inhibitor,inhibit,biased,β-arrestin,MLS1547,Dopamine Receptor,protein,signaling,recruitment
- CBNumber
- CB53067562
- Molecular Formula
- C19H19ClN4O
- Formula Weight
- 354.83
- MOL File
- 315698-36-3.mol
MLS1547 Property
- Boiling point:
- 555.8±50.0 °C(Predicted)
- Density
- 1.354±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
- form
- A crystalline solid
- pka
- 4.08±0.30(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1331
- Product name
- MLS1547
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $100
- Updated
- 2025/07/31
- Product number
- SML1331
- Product name
- MLS1547
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $393
- Updated
- 2025/07/31
- Product number
- 27648
- Product name
- MLS-1547
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 27648
- Product name
- MLS-1547
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 27648
- Product name
- MLS-1547
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
MLS1547 Chemical Properties,Usage,Production
Uses
MLS 1547 is a dopamine D2 receptor partial agonist which may be used in the preparation of or combination with antipsychotic drugs.
Biological Activity
MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist th at does not recruit β-arrestin, and is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor. MLS-1547 is the first D2 receptor agonist with close to full efficacy for G protein signaling (EC50 = 370 nM), but no ability to recruit β-arrestin.
IC 50
D2 Receptor
storage
Store at +4°C
MLS1547 Preparation Products And Raw materials
Raw materials
Preparation Products
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