ChemicalBook > CAS DataBase List > 6-BROMO-2-METHYLBENZODOXAZOLE

6-BROMO-2-METHYLBENZODOXAZOLE

Product Name
6-BROMO-2-METHYLBENZODOXAZOLE
CAS No.
151230-42-1
Chemical Name
6-BROMO-2-METHYLBENZODOXAZOLE
Synonyms
6-BROMO-2-METHYLBENZOXAZOLE;6-BROMO-2-METHYLBENZODOXAZOLE;6-Bromo-2-methyl-benzooxazole;Benzoxazole, 6-bromo-2-methyl-;6-BroMo-2-Methyl-1,3-benzoxazole
CBNumber
CB5309757
Molecular Formula
C8H6BrNO
Formula Weight
212.04
MOL File
151230-42-1.mol
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6-BROMO-2-METHYLBENZODOXAZOLE Property

Melting point:
44-49°C
Boiling point:
264.8±13.0 °C(Predicted)
Density 
1.606±0.06 g/cm3(Predicted)
Flash point:
>110℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
solid
pka
-0.09±0.30(Predicted)
Appearance
Yellow to orange Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
761729
Product name
6-Bromo-2-methylbenzoxazole
Purity
97%
Packaging
500mg
Price
$110
Updated
2023/06/20
TRC
Product number
B697105
Product name
6-Bromo-2-methyl-1,3-benzoxazole
Packaging
500mg
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140691
Product name
6-Bromo-2-methylbenzo[d]oxazole
Packaging
1g
Price
$111
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140691
Product name
6-Bromo-2-methylbenzo[d]oxazole
Packaging
500mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
Z4197
Product name
6-Bromo-2-methylbenzo[d]oxazole
Packaging
250mg
Price
$74
Updated
2021/12/16
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6-BROMO-2-METHYLBENZODOXAZOLE Chemical Properties,Usage,Production

Synthesis

38191-34-3

78-39-7

151230-42-1

Using 2-amino-5-bromophenol (561 mg, 3.00 mmol) and triethyl orthoacetate (656 μL, 3.6 mmol) as the raw material, 1,3-dibromo-5,5-dimethylglycolonide (17.2 mg, 0.060 mmol) was added as a catalyst. The reaction mixture was stirred at room temperature for 10 min. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (50 mL × 2). The organic layers were combined, washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography using ethyl acetate/hexane (1:4, v/v) as eluent to afford 6-bromo-2-methylbenzoxazole (560 mg, 88.5% yield).

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7241 - 7257
[2] Patent: JP2016/79108, 2016, A. Location in patent: Paragraph 0063
[3] Patent: WO2012/151525, 2012, A1. Location in patent: Page/Page column 128
[4] Patent: US2012/289496, 2012, A1. Location in patent: Page/Page column 113

6-BROMO-2-METHYLBENZODOXAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-2-METHYLBENZODOXAZOLE Suppliers

China 85 India 2 United Kingdom 1 United States 7 Global 95
Tetranov Biopharm
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13526569071
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sales@leadmedpharm.com
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China
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Shanghai XR Chemical Technology Co., Ltd.
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Sigma-Aldrich
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orderCN@merckgroup.com
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151230-42-1, 6-BROMO-2-METHYLBENZODOXAZOLERelated Search:

2-Methylbenzoxazole 4-BROMO-A23187 4,6-DIBROMO-2-(3-BROMOPHENYL)-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(2-BROMOPHENYL)-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(3-FLUOROPHENYL)-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(3,4-DICHLOROPHENYL)-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-PHENYL-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(3,4-DIMETHYLPHENYL)-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(4-TERT-BUTYLPHENYL)-1,3-BENZOXAZOL-5-AMINE 2-(1,1'-BIPHENYL-4-YL)-4,6-DIBROMO-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(3-CHLOROPHENYL)-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(2-CHLORO-PHENYL)-BENZOOXAZOL-5-YLAMINE 4,6-DIBROMO-2-(5-CHLORO-1-NAPHTHYL)-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(4-METHYLPHENYL)-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(2-CHLORO-4-METHYLPHENYL)-1,3-BENZOXAZOL-5-AMINE 4,6-DIBROMO-2-(4-FLUOROPHENYL)-1,3-BENZOXAZOL-5-AMINE ASISCHEM U66090 4,6-DIBROMO-2-(4-METHOXYPHENYL)-1,3-BENZOXAZOL-5-AMINE

  • 6-BROMO-2-METHYLBENZODOXAZOLE
  • 6-BROMO-2-METHYLBENZOXAZOLE
  • 6-BroMo-2-Methyl-1,3-benzoxazole
  • 6-Bromo-2-methyl-benzooxazole
  • Benzoxazole, 6-bromo-2-methyl-
  • 151230-42-1