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GPRP (acetate)

Product Name
GPRP (acetate)
CAS No.
157009-81-9
Chemical Name
GPRP (acetate)
Synonyms
Pefa 6003;Pefabloc FG);GPRP (acetate);GPRP ACETATE, >98%;H-Gly-Pro-Arg-Pro-OH (acetate);GPRP acetate (67869-62-9 free base);GLY-PRO-ARG-PRO ACETATE;PEFABLOC FG;GPRP acetate (Gly-Pro-Arg-Pro acetate;L-Proline, glycyl-L-prolyl-L-arginyl-, acetate (1:1);GPRP acetate,Gly-Pro-Arg-Pro acetate,Glycyl-L-prolyl-L-arginyl-L-proline acetate,Pefa 6003,Pefabloc FG, >98%
CBNumber
CB53121103
Molecular Formula
C20H35N7O7
Formula Weight
485.54
MOL File
157009-81-9.mol
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GPRP (acetate) Property

solubility 
PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
White to off-white
Sequence
H-Gly-Pro-Arg-Pro-OH
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21163
Product name
H-Gly-Pro-Arg-Pro-OH (acetate)
Purity
≥95%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
21163
Product name
H-Gly-Pro-Arg-Pro-OH (acetate)
Purity
≥95%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
21163
Product name
H-Gly-Pro-Arg-Pro-OH (acetate)
Purity
≥95%
Packaging
10mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
21163
Product name
H-Gly-Pro-Arg-Pro-OH (acetate)
Purity
≥95%
Packaging
25mg
Price
$161
Updated
2024/03/01
AK Scientific
Product number
6190EF
Product name
GPRPacetate
Packaging
1mg
Price
$128
Updated
2021/12/16
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GPRP (acetate) Chemical Properties,Usage,Production

Uses

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3].

in vivo

GPRP acetate (100 mg/kg; i.p., once daily for 10 days) significantly alleviates DSS-induced colitis through the improvement of body weight loss and mortality[3].

Animal Model:C57BL/6 mice with dextran sulphate sodium (DSS)-induced colitis[3]
Dosage:100 mg/kg
Administration:Intraperitoneal injection; 100 mg/kg, once daily, for 10 days
Result:Significantly inhibited body weight loss and reduced DSS-induced mortality and shortening of colon length, and decreased tissue damage and infiltration of inflammatory cells in colitis mice. Decreased levels of inflammatory cytokines in colitis mice.

References

[1] Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78(6):547-50. DOI:10.1016/0049-3848(95)e0088-8
[2] Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24(3): 322-7. DOI:10.1021/jm00135a016
[3] Zhang C, et al. Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. Cell Mol Gastroenterol Hepatol. 2021;11(3):683-696. DOI:10.1016/j.jcmgh.2020.10.007

GPRP (acetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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GPRP (acetate) Suppliers

China 53 United States 7 Global 60
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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4861
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Creative Peptides
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Email
info@creative-peptides.com
Country
United States
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6083
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BOC Sciences
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+1-631-485-4226
Fax
1-631-614-7828
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inquiry@bocsci.com
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United States
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19552
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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58
Cayman Chemical Company
Tel
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Fax
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Email
cayman@caymanchem.com
Country
United States
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MedChemExpress
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Email
sales@medchemexpress.com
Country
United States
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6398
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157009-81-9, GPRP (acetate)Related Search:

FIBRINOGEN GAMMA-CHAIN (117-133) FIBRINOGEN GAMMA-CHAIN (397-411) FIBRONECTIN CS-1 FRAGMENT (1978-1985) HIS-HIS-LEU-GLY-GLY-ALA-LYS-GLN-ALA-GLY-ASP-VAL FIBRINOPEPTIDE B

  • GPRP acetate (Gly-Pro-Arg-Pro acetate
  • Pefabloc FG)
  • GPRP ACETATE, >98%
  • GPRP acetate,Gly-Pro-Arg-Pro acetate,Glycyl-L-prolyl-L-arginyl-L-proline acetate,Pefa 6003,Pefabloc FG, >98%
  • GLY-PRO-ARG-PRO ACETATE;PEFABLOC FG
  • GPRP (acetate)
  • H-Gly-Pro-Arg-Pro-OH (acetate)
  • Pefa 6003
  • GPRP acetate (67869-62-9 free base)
  • L-Proline, glycyl-L-prolyl-L-arginyl-, acetate (1:1)
  • fibrinogen,GPRP acetate (67869 62 9 free base),Fibrin,inhibit,polymerization,GPRP,Pefa6003,IIb/IIIa,Pefa-6003,GPIIb/IIIa,glycoprotein,Inhibitor,platelet,GPRP acetate (67869629 free base)
  • (S)-1-((S)-2-((S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid compound with acetic acid (1:1)
  • (S)-1-((S)-2-((S)-1-(2-Aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid acetate
  • 157009-81-9