ChemicalBook > CAS DataBase List > jnj39758979

jnj39758979

Product Name: jnj39758979
CAS No.: 1046447-90-8
Chemical Name: jnj39758979
Synonyms: jnj39758979;JNJ-39758979, 10 mM in DMSO;JNJ 39758979 (JNJ-39758979;(R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine;4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-6-PROPAN-2-YLPYRIMIDIN-2-AMINE;2-Pyrimidinamine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)-;agranulocytosis,histamine,JNJ-39758979,selective,toxicity,JNJ39758979,cAMP,inhibit,oral,Histamine Receptor,anti-inflammatory,Inhibitor,antipruritic,JNJ 39758979
CBNumber: CB53121976
Molecular Formula: C11H19N5
Formula Weight: 221.3
MOL File: 1046447-90-8.mol

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jnj39758979 Property

storage temp.: 4°C, protect from light
solubility: Chloroform (Slightly), DMSO (Slightly, Sonicated)
form: Solid
color: Pale Beige to Light Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: J212500
Product name: JNJ39758979
Packaging: 1mg
Price: $60
Updated: 2021/12/16

TRC

Product number: J212500
Product name: JNJ39758979
Packaging: 2.5mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-0020957
Product name: JNJ-39758979
Purity: ≥98.0%
Packaging: 1mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-0020957
Product name: JNJ-39758979
Purity: ≥98.0%
Packaging: 5mg
Price: $396
Updated: 2021/12/16

ChemScene

Product number: CS-0020957
Product name: JNJ-39758979
Purity: ≥98.0%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

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jnj39758979 Chemical Properties,Usage,Production

Uses

JNJ 39758979, is a selective, high-affinity histamine H4 receptor antagonist with a Ki of 12.5 nM.

in vivo

JNJ-39758979 (10 mg/kg; p.o.) treatment shows that the C_max, t_1/2 and F values are 0.3 μM, 7.5 hours, and 36%, respectively^[1].
JNJ-39758979 (2 mg/kg; i.v.) treatment shows that the Vss, AUC, CL and t_1/2 were 19.9 L/kg, 1.4 μM*h, 2.2 L/h, and 2.1 hours, respectively ^[1].

Animal Model:	Sprague-Dawley rats^[1]
Dosage:	10 mg/kg
Administration:	Oral administration (Pharmacokinetic Analysis)
Result:	The C_max, t_1/2 and F values were 0.3 μM, 7.5 hours, and 36%, respectively.

IC 50

Human H₄ Receptor: 12.5 nM (Ki); Mouse H₄ Receptor: 5.3 nM (Ki); Monkey H₄ receptor: 25 nM (Ki); Rat H₄ receptor: 188 nM (Ki); Guinea pig H₄ receptor: 306 nM (Ki)

jnj39758979 Preparation Products And Raw materials

Raw materials

Preparation Products

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jnj39758979 Suppliers

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1046447-90-8, jnj39758979Related Search:

JNJ7777120 JNJ-64619178 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide MELK-T1(JNJ-47117096) JNJ-632

jnj39758979

4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-6-PROPAN-2-YLPYRIMIDIN-2-AMINE

JNJ 39758979 (JNJ-39758979

2-Pyrimidinamine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)-

(R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine

agranulocytosis,histamine,JNJ-39758979,selective,toxicity,JNJ39758979,cAMP,inhibit,oral,Histamine Receptor,anti-inflammatory,Inhibitor,antipruritic,JNJ 39758979

JNJ-39758979, 10 mM in DMSO

1046447-90-8