ChemicalBook > CAS DataBase List > HLCL-61 (hydrochloride)

HLCL-61 (hydrochloride)

Product Name
HLCL-61 (hydrochloride)
CAS No.
1158279-20-9
Chemical Name
HLCL-61 (hydrochloride)
Synonyms
CS-2798;HLCL-61.HCl;HLCL61;HLCL 61;HLCL-61 (hydrochloride);HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE;1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride;Histone Methyltransferase,HLCL 61,HLCL-61,inhibit,HLCL 61 hydrochloride,Apoptosis,HLCL61 hydrochloride,Inhibitor
CBNumber
CB53122928
Molecular Formula
C23H25ClN2O
Formula Weight
380.92
MOL File
1158279-20-9.mol
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HLCL-61 (hydrochloride) Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
≥20.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19897
Product name
HLCL-61 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19897
Product name
HLCL-61 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
19897
Product name
HLCL-61 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
19897
Product name
HLCL-61 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$321
Updated
2024/03/01
ChemScene
Product number
CS-5600
Product name
HLCL-61(hydrochloride)
Purity
99.98%
Packaging
100mg
Price
$540
Updated
2021/12/16
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HLCL-61 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

hlcl-61 is a prmt5 inhibitor.aberrant methylation of protein arginine residues mediated by protein arginine methyltransferase (prmt) enzymes is reported to be linked to cancer. prmts are a family of proteins with 11 known members catalyzing the transfer of methyl group(s) to the guanidine nitrogen atoms of peptide arginine residues. prmt5 has multiple substrates including histones and other non-chromatin proteins and has been gained attention for cancer therapy.

in vitro

in previous study, hlcl-61 showed no inhibitory activity against prmt1, prmt4, and type ii prmt family members, therefore demonstrating its specificity for prmt5. hlcl-61 also showed effective inhibition of symmetric arginine dimethylation of histones h3 and h4, starting at 12 h posttreatment and persisting for 48 h. moreover, the treatment of aml cell lines and primary blasts with hlcl-61 led to the decrease of cell viability. in addition, hlcl-61-treated aml cell lines and patient samples had induction of differentiation as demonstrated by dose-dependent increases in the expression of cd11b. furthermore, prmt5 inhibition caused by hlcl-61 treatment led to a decrease in mv4-11 cells [1].

target

Protein arginine methyltransferase 5

References

[1] tarighat ss et al. the dual epigenetic role of prmt5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. leukemia. 2016 apr;30(4):789-99.

HLCL-61 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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HLCL-61 (hydrochloride) Suppliers

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1158279-20-9, HLCL-61 (hydrochloride)Related Search:

8-Ethyl-1,3,4,9-tetrahydro-1-methylpyrano[3,4-b]indole-1-acetic acid

  • HLCL-61 (hydrochloride)
  • HLCL-61.HCl
  • HLCL61;HLCL 61
  • CS-2798
  • HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE
  • 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
  • Histone Methyltransferase,HLCL 61,HLCL-61,inhibit,HLCL 61 hydrochloride,Apoptosis,HLCL61 hydrochloride,Inhibitor
  • 1158279-20-9
  • API