HLCL-61 (hydrochloride)
- Product Name
- HLCL-61 (hydrochloride)
- CAS No.
- 1158279-20-9
- Chemical Name
- HLCL-61 (hydrochloride)
- Synonyms
- CS-2798;HLCL-61.HCl;HLCL61;HLCL 61;HLCL-61 (hydrochloride);HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE;1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride;Histone Methyltransferase,HLCL 61,HLCL-61,inhibit,HLCL 61 hydrochloride,Apoptosis,HLCL61 hydrochloride,Inhibitor
- CBNumber
- CB53122928
- Molecular Formula
- C23H25ClN2O
- Formula Weight
- 380.92
- MOL File
- 1158279-20-9.mol
HLCL-61 (hydrochloride) Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- ≥20.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- crystalline solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19897
- Product name
- HLCL-61 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 19897
- Product name
- HLCL-61 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 19897
- Product name
- HLCL-61 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 19897
- Product name
- HLCL-61 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- CS-5600
- Product name
- HLCL-61(hydrochloride)
- Purity
- 99.98%
- Packaging
- 100mg
- Price
- $540
- Updated
- 2021/12/16
HLCL-61 (hydrochloride) Chemical Properties,Usage,Production
Biological Activity
hlcl-61 is a prmt5 inhibitor.aberrant methylation of protein arginine residues mediated by protein arginine methyltransferase (prmt) enzymes is reported to be linked to cancer. prmts are a family of proteins with 11 known members catalyzing the transfer of methyl group(s) to the guanidine nitrogen atoms of peptide arginine residues. prmt5 has multiple substrates including histones and other non-chromatin proteins and has been gained attention for cancer therapy.
in vitro
in previous study, hlcl-61 showed no inhibitory activity against prmt1, prmt4, and type ii prmt family members, therefore demonstrating its specificity for prmt5. hlcl-61 also showed effective inhibition of symmetric arginine dimethylation of histones h3 and h4, starting at 12 h posttreatment and persisting for 48 h. moreover, the treatment of aml cell lines and primary blasts with hlcl-61 led to the decrease of cell viability. in addition, hlcl-61-treated aml cell lines and patient samples had induction of differentiation as demonstrated by dose-dependent increases in the expression of cd11b. furthermore, prmt5 inhibition caused by hlcl-61 treatment led to a decrease in mv4-11 cells [1].
target
Protein arginine methyltransferase 5
References
[1] tarighat ss et al. the dual epigenetic role of prmt5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. leukemia. 2016 apr;30(4):789-99.
HLCL-61 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
HLCL-61 (hydrochloride) Suppliers
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