ChemicalBook > CAS DataBase List > TA-01

TA-01

Product Name
TA-01
CAS No.
1784751-18-3
Chemical Name
TA-01
Synonyms
TA-01;TA-01;TA01;TA 01;TA 01,Inhibitor,Casein Kinase,Autophagy,p38 MAPK,inhibit,TA01,TA-01;4-(2-(2,6-Difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine;Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-
CBNumber
CB53122933
Molecular Formula
C20H12F3N3
Formula Weight
351.32
MOL File
1784751-18-3.mol
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TA-01 Property

Boiling point:
511.1±50.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml; DMSO: 3 mg/ml
form 
A crystalline solid
pka
9.26±0.24(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24667
Product name
TA-01
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24667
Product name
TA-01
Purity
≥98%
Packaging
5mg
Price
$145
Updated
2024/03/01
Cayman Chemical
Product number
24667
Product name
TA-01
Purity
≥98%
Packaging
10mg
Price
$275
Updated
2024/03/01
Cayman Chemical
Product number
24667
Product name
TA-01
Purity
≥98%
Packaging
25mg
Price
$571
Updated
2024/03/01
TRC
Product number
T779005
Product name
TA01
Packaging
50mg
Price
$875
Updated
2021/12/16
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TA-01 Chemical Properties,Usage,Production

Description

TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic at concentrations less than 5 μM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1ε (CK1ε) and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.

Uses

TA 01 induces cardiomyocyte differentiation of pluripotent stem cells.

TA-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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TA-01 Suppliers

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1784751-18-3, TA-01Related Search:

TA-02

  • TA-01;TA01;TA 01
  • TA-01
  • Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-
  • 4-(2-(2,6-Difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine
  • TA 01,Inhibitor,Casein Kinase,Autophagy,p38 MAPK,inhibit,TA01,TA-01
  • 1784751-18-3
  • C20H12F3N3