ChemicalBook > CAS DataBase List > TA-01

TA-01

Product Name: TA-01
CAS No.: 1784751-18-3
Chemical Name: TA-01
Synonyms: TA-01;TA-01 ，S0186;TA-01;TA01;TA 01;TA-01, 10 mM in DMSO;TA 01,Inhibitor,Casein Kinase,Autophagy,p38 MAPK,inhibit,TA01,TA-01;4-(2-(2,6-Difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine;Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-
CBNumber: CB53122933
Molecular Formula: C20H12F3N3
Formula Weight: 351.32
MOL File: 1784751-18-3.mol

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TA-01 Property

Boiling point:: 511.1±50.0 °C(Predicted)
Density: 1.337±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml; DMSO: 3 mg/ml
form: A crystalline solid
pka: 9.26±0.24(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24667
Product name: TA-01
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24667
Product name: TA-01
Purity: ≥98%
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 24667
Product name: TA-01
Purity: ≥98%
Packaging: 10mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 24667
Product name: TA-01
Purity: ≥98%
Packaging: 25mg
Price: $571
Updated: 2024/03/01

TRC

Product number: T779005
Product name: TA01
Packaging: 50mg
Price: $875
Updated: 2021/12/16

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TA-01 Chemical Properties,Usage,Production

Description

TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic at concentrations less than 5 μM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5^eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1ε (CK1ε) and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.

Uses

TA 01 induces cardiomyocyte differentiation of pluripotent stem cells.

IC 50

CKIδ: 6.8 nM (IC₅₀); p38 MAP kinase: 6.7 nM (IC₅₀)

References

[1] FILIP LACO . Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling[J]. Journal of molecular and cellular cardiology, 2015, 80: Pages 56-70. DOI: 10.1016/j.yjmcc.2014.12.003

TA-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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1784751-18-3, TA-01Related Search:

TA-02

TA-01;TA01;TA 01

TA-01

Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-

4-(2-(2,6-Difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine

TA 01,Inhibitor,Casein Kinase,Autophagy,p38 MAPK,inhibit,TA01,TA-01

TA-01, 10 mM in DMSO

TA-01 ，S0186

1784751-18-3

C20H12F3N3