TA-01
- Product Name
- TA-01
- CAS No.
- 1784751-18-3
- Chemical Name
- TA-01
- Synonyms
- TA-01;TA-01;TA01;TA 01;TA 01,Inhibitor,Casein Kinase,Autophagy,p38 MAPK,inhibit,TA01,TA-01;4-(2-(2,6-Difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine;Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-
- CBNumber
- CB53122933
- Molecular Formula
- C20H12F3N3
- Formula Weight
- 351.32
- MOL File
- 1784751-18-3.mol
TA-01 Property
- Boiling point:
- 511.1±50.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml; DMSO: 3 mg/ml
- form
- A crystalline solid
- pka
- 9.26±0.24(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 24667
- Product name
- TA-01
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 24667
- Product name
- TA-01
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 24667
- Product name
- TA-01
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 24667
- Product name
- TA-01
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $571
- Updated
- 2024/03/01
- Product number
- T779005
- Product name
- TA01
- Packaging
- 50mg
- Price
- $875
- Updated
- 2021/12/16
TA-01 Chemical Properties,Usage,Production
Description
TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic at concentrations less than 5 μM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1ε (CK1ε) and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.
Uses
TA 01 induces cardiomyocyte differentiation of pluripotent stem cells.