BVD523
- Product Name
- BVD523
- CAS No.
- 1956366-10-1
- Chemical Name
- BVD523
- Synonyms
- BVD523;Ulixertinib HCl;Ulixertinib HCl salt;VRT752271 hydrochloride);Ulixertinib hydrochloride;Ulixertinib hydrochloride (BVD-523 hydrochloride;Ulixertinib hydrochloride (Synonyms: BVD-523 hydrochloride;ULIXERTINIB HYDROCHLORIDE (SYNONYMS: BVD-523 HYDROCHLORIDE; VRT752271 HYDROCHLORIDE);(S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamidehydrochloride
- CBNumber
- CB53133892
- Molecular Formula
- C21H23Cl3N4O2
- Formula Weight
- 469.79192
- MOL File
- 1956366-10-1.mol
BVD523 Property
- Melting point:
- 231-232°C
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18298
- Product name
- Ulixertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 18298
- Product name
- Ulixertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 18298
- Product name
- Ulixertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $99
- Updated
- 2024/03/01
- Product number
- 18298
- Product name
- Ulixertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- U700835
- Product name
- UlixertinibHydrochloride
- Packaging
- 250mg
- Price
- $345
- Updated
- 2021/12/16
BVD523 Chemical Properties,Usage,Production
Description
Ulixertinib is a reversible ERK1/2 inhibitor that demonstrates an IC50 value of <0.3 nM for ERK2. In A375 melanoma cells with b-RafV600E mutation, it has been reported to reduce the levels of phosphorylated ERK2 and the downstream kinase RSK (IC50s = 4.1 and 0.14 μM, respectively). Ulixertinib has also been shown to inhibit A375 cell proliferation with an IC50 value of 180 nM.
Uses
Ulixertinib Hydrochloride is an acid salt of Ulixertinib (U700830), a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Inhibits cell proliferation. Anti-cancer.
in vitro
in two lymphoma cell lines (sudhl-10 and raji), treatment with ulixertinib significantly reduced the expression of erk1/2 phosphorylation in a dose-dependent manner. treatment with 0.4 nm ulixertinib decreased the percentage of g2-m phase cells in the sudhl-10 cells. in the raji cells, treated with ulixertinib at 0.4 and 1.0 nm increased the percentage of g0-g1 phase cells and decreased s phase cells [1]. treatment of ulixertinib at the dose of 0.1, 0.4 and 1.0 nm for 48 h dose-dependently increased the number of early apoptotic sudhl- 10 and raji cells [1]. in sudhl-10 and raji cells, ulixertinib reduced mrna and protein expression of vegfr2 and bcl-2 genes and increased the expression of bax and caspase-3 genes [1].
in vivo
bvd-523 inhibited tumor growth in braf-mutant melanoma and colorectal xenografts as well as in kras-mutant colorectal and pancreatic models. bvd-523 treatment in combination with dabrafenib inhibited tumor growth in a braf-mutant melanoma model [3]. single-agent bvd-523 inhibited the growth of a patient-derived tumor xenograft harboring cross-resistance to dabrafenib, trametinib, and the combination treatment following clinical progression on a mek inhibitor [3].
BVD523 Preparation Products And Raw materials
Raw materials
Preparation Products
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