Ulixertinib hydrochloride

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Ulixertinib hydrochloride

Configuration method

Product Name: Ulixertinib hydrochloride
CAS No.: 1956366-10-1
Chemical Name: Ulixertinib hydrochloride
Synonyms: BVD523;Ulixertinib HCl;Ulixertinib HCl salt;VRT752271 hydrochloride);Ulixertinib hydrochloride;Ulixertinib hydrochloride (BVD-523 hydrochloride;Ulixertinib hydrochloride (Synonyms: BVD-523 hydrochloride;ULIXERTINIB HYDROCHLORIDE (SYNONYMS: BVD-523 HYDROCHLORIDE; VRT752271 HYDROCHLORIDE);(S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamidehydrochloride
CBNumber: CB53133892
Molecular Formula: C21H23Cl3N4O2
Formula Weight: 469.79192
MOL File: 1956366-10-1.mol

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Ulixertinib hydrochloride Property

Melting point:: 231-232°C
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1/C21H22Cl2N4O2.ClH/c1-12(2)26-20-8-16(17(23)10-25-20)14-7-18(24-9-14)21(29)27-19(11-28)13-4-3-5-15(22)6-13;/h3-10,12,19,24,28H,11H2,1-2H3,(H,25,26)(H,27,29);1H/t19-;/s3
InChIKey: DKGYQCPFBWFTHM-JHTMQSDJNA-N
SMILES: O=C(N[C@H](CO)C1C=C(Cl)C=CC=1)C1NC=C(C2C(Cl)=CN=C(NC(C)C)C=2)C=1.Cl |&1:3,r|

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18298
Product name: Ulixertinib (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 18298
Product name: Ulixertinib (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 18298
Product name: Ulixertinib (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $99
Updated: 2024/03/01

Cayman Chemical

Product number: 18298
Product name: Ulixertinib (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $141
Updated: 2024/03/01

TRC

Product number: U700835
Product name: UlixertinibHydrochloride
Packaging: 250mg
Price: $345
Updated: 2021/12/16

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Ulixertinib hydrochloride Chemical Properties,Usage,Production

Configuration method

Ulixertinib (hydrochloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the ulixertinib (hydrochloride) in the solvent of choice, which should be purged with an inert gas. Ulixertinib (hydrochloride) is soluble in organic solvents such as ethanol, DMSO, and dimethylformamide (DMF). The solubility of this compound in ethanol is approximately 1 mg/ml and approximately 30 mg/ml in DMSO and DMF. Ulixertinib(hydrochloride) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers,ulixertinib (hydrochloride) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Ulixertinib (hydrochloride) has a solubility of approximately 0.25 mg/ml in a 1:3 solution of DMSO: PBS (pH 7.2) using this method.

Description

Ulixertinib is a reversible ERK1/2 inhibitor that demonstrates an IC₅₀ value of <0.3 nM for ERK2. In A375 melanoma cells with b-Raf^V600E mutation, it has been reported to reduce the levels of phosphorylated ERK2 and the downstream kinase RSK (IC₅₀s = 4.1 and 0.14 μM, respectively). Ulixertinib has also been shown to inhibit A375 cell proliferation with an IC₅₀ value of 180 nM.

Uses

Ulixertinib Hydrochloride is an acid salt of Ulixertinib (U700830), a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Inhibits cell proliferation. Anti-cancer.

Uses

Ulixertinib hydrochloride is a potent in vitro inhibitor of ERK1/2 kinase that contacts myogenic precursor cells in farmed animals, thereby promoting fusion and myogenic maturation for industrial meat production.

in vitro

in two lymphoma cell lines (sudhl-10 and raji), treatment with ulixertinib significantly reduced the expression of erk1/2 phosphorylation in a dose-dependent manner. treatment with 0.4 nm ulixertinib decreased the percentage of g2-m phase cells in the sudhl-10 cells. in the raji cells, treated with ulixertinib at 0.4 and 1.0 nm increased the percentage of g0-g1 phase cells and decreased s phase cells [1]. treatment of ulixertinib at the dose of 0.1, 0.4 and 1.0 nm for 48 h dose-dependently increased the number of early apoptotic sudhl- 10 and raji cells [1]. in sudhl-10 and raji cells, ulixertinib reduced mrna and protein expression of vegfr2 and bcl-2 genes and increased the expression of bax and caspase-3 genes [1].

in vivo

bvd-523 inhibited tumor growth in braf-mutant melanoma and colorectal xenografts as well as in kras-mutant colorectal and pancreatic models. bvd-523 treatment in combination with dabrafenib inhibited tumor growth in a braf-mutant melanoma model [3]. single-agent bvd-523 inhibited the growth of a patient-derived tumor xenograft harboring cross-resistance to dabrafenib, trametinib, and the combination treatment following clinical progression on a mek inhibitor [3].

Ulixertinib hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1956366-10-1, Ulixertinib hydrochlorideRelated Search:

BVD523

(S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamidehydrochloride

Ulixertinib hydrochloride

Ulixertinib HCl salt

Ulixertinib HCl

Ulixertinib hydrochloride (BVD-523 hydrochloride

VRT752271 hydrochloride)

Ulixertinib hydrochloride (Synonyms: BVD-523 hydrochloride

ULIXERTINIB HYDROCHLORIDE (SYNONYMS: BVD-523 HYDROCHLORIDE; VRT752271 HYDROCHLORIDE)

1956366-10-1