Configuration method
ChemicalBook > CAS DataBase List > Ulixertinib hydrochloride

Ulixertinib hydrochloride

Configuration method
Product Name
Ulixertinib hydrochloride
CAS No.
1956366-10-1
Chemical Name
Ulixertinib hydrochloride
Synonyms
BVD523;Ulixertinib HCl;Ulixertinib HCl salt;VRT752271 hydrochloride);Ulixertinib hydrochloride;Ulixertinib hydrochloride (BVD-523 hydrochloride;Ulixertinib hydrochloride (Synonyms: BVD-523 hydrochloride;ULIXERTINIB HYDROCHLORIDE (SYNONYMS: BVD-523 HYDROCHLORIDE; VRT752271 HYDROCHLORIDE);(S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamidehydrochloride
CBNumber
CB53133892
Molecular Formula
C21H23Cl3N4O2
Formula Weight
469.79192
MOL File
1956366-10-1.mol
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Ulixertinib hydrochloride Property

Melting point:
231-232°C
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1/C21H22Cl2N4O2.ClH/c1-12(2)26-20-8-16(17(23)10-25-20)14-7-18(24-9-14)21(29)27-19(11-28)13-4-3-5-15(22)6-13;/h3-10,12,19,24,28H,11H2,1-2H3,(H,25,26)(H,27,29);1H/t19-;/s3
InChIKey
DKGYQCPFBWFTHM-JHTMQSDJNA-N
SMILES
O=C(N[C@H](CO)C1C=C(Cl)C=CC=1)C1NC=C(C2C(Cl)=CN=C(NC(C)C)C=2)C=1.Cl |&1:3,r|
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18298
Product name
Ulixertinib (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$29
Updated
2024/03/01
Cayman Chemical
Product number
18298
Product name
Ulixertinib (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
18298
Product name
Ulixertinib (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$99
Updated
2024/03/01
Cayman Chemical
Product number
18298
Product name
Ulixertinib (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$141
Updated
2024/03/01
TRC
Product number
U700835
Product name
UlixertinibHydrochloride
Packaging
250mg
Price
$345
Updated
2021/12/16
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Ulixertinib hydrochloride Chemical Properties,Usage,Production

Configuration method

Ulixertinib (hydrochloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the ulixertinib (hydrochloride) in the solvent of choice, which should be purged with an inert gas. Ulixertinib (hydrochloride) is soluble in organic solvents such as ethanol, DMSO, and dimethylformamide (DMF). The solubility of this compound in ethanol is approximately 1 mg/ml and approximately 30 mg/ml in DMSO and DMF. Ulixertinib(hydrochloride) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers,ulixertinib (hydrochloride) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Ulixertinib (hydrochloride) has a solubility of approximately 0.25 mg/ml in a 1:3 solution of DMSO: PBS (pH 7.2) using this method.

Description

Ulixertinib is a reversible ERK1/2 inhibitor that demonstrates an IC50 value of <0.3 nM for ERK2. In A375 melanoma cells with b-RafV600E mutation, it has been reported to reduce the levels of phosphorylated ERK2 and the downstream kinase RSK (IC50s = 4.1 and 0.14 μM, respectively). Ulixertinib has also been shown to inhibit A375 cell proliferation with an IC50 value of 180 nM.

Uses

Ulixertinib Hydrochloride is an acid salt of Ulixertinib (U700830), a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Inhibits cell proliferation. Anti-cancer.

Uses

Ulixertinib hydrochloride is a potent in vitro inhibitor of ERK1/2 kinase that contacts myogenic precursor cells in farmed animals, thereby promoting fusion and myogenic maturation for industrial meat production.

in vitro

in two lymphoma cell lines (sudhl-10 and raji), treatment with ulixertinib significantly reduced the expression of erk1/2 phosphorylation in a dose-dependent manner. treatment with 0.4 nm ulixertinib decreased the percentage of g2-m phase cells in the sudhl-10 cells. in the raji cells, treated with ulixertinib at 0.4 and 1.0 nm increased the percentage of g0-g1 phase cells and decreased s phase cells [1]. treatment of ulixertinib at the dose of 0.1, 0.4 and 1.0 nm for 48 h dose-dependently increased the number of early apoptotic sudhl- 10 and raji cells [1]. in sudhl-10 and raji cells, ulixertinib reduced mrna and protein expression of vegfr2 and bcl-2 genes and increased the expression of bax and caspase-3 genes [1].

in vivo

bvd-523 inhibited tumor growth in braf-mutant melanoma and colorectal xenografts as well as in kras-mutant colorectal and pancreatic models. bvd-523 treatment in combination with dabrafenib inhibited tumor growth in a braf-mutant melanoma model [3]. single-agent bvd-523 inhibited the growth of a patient-derived tumor xenograft harboring cross-resistance to dabrafenib, trametinib, and the combination treatment following clinical progression on a mek inhibitor [3].

Ulixertinib hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Ulixertinib hydrochloride Suppliers

China 40 India 2 United States 4 USA 1 Global 47
Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
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China
ProdList
595
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55
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
5797
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58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
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61
Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
965
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58
Shanghai XingMo Biotechnology Co., Ltd.
Tel
13524779951
Fax
QQ: 2075692521
Email
2075692521@qq.com
Country
China
ProdList
310
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55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4512
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55
Guangzhou Zhiya Chemdrugs Co.,Ltd
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18122150900
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QQ:2869377561
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sculk28@163.com
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China
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646
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ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
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62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
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58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
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7268
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58

1956366-10-1, Ulixertinib hydrochlorideRelated Search:


  • BVD523
  • (S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamidehydrochloride
  • Ulixertinib hydrochloride
  • Ulixertinib HCl salt
  • Ulixertinib HCl
  • Ulixertinib hydrochloride (BVD-523 hydrochloride
  • VRT752271 hydrochloride)
  • Ulixertinib hydrochloride (Synonyms: BVD-523 hydrochloride
  • ULIXERTINIB HYDROCHLORIDE (SYNONYMS: BVD-523 HYDROCHLORIDE; VRT752271 HYDROCHLORIDE)
  • 1956366-10-1