ChemicalBook > CAS DataBase List > FOXY-5

FOXY-5

Product Name: FOXY-5
CAS No.: 881188-51-8
Chemical Name: FOXY-5
Synonyms: FOXY-5;Foxy-5 ，S6961;Foxy 5 trifluoroacetic acid;Foxy-5(Wnt5a peptide mimetic);Foxy 5 Discontinued (see F746005);L-Leucine, N-formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl-;N-formyl-L-methionyl-L-alpha-aspartyl-glycyl-L-cysteinyl-L-alpha-glutamyl-L-leucine;(2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecane-1,16-dioic acid;(2S,5S,8R,14S)-5-(2-Carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butancarboxcarboxcarboxamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecan-1,16-dioic acid
CBNumber: CB53143800
Molecular Formula: C26H42N6O12S2
Formula Weight: 694.77
MOL File: 881188-51-8.mol

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FOXY-5 Property

Boiling point:: 1244.1±65.0 °C(Predicted)
Density: 1.368±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 3.34±0.10(Predicted)
color: White to off-white
Sequence: {For}-Met-Asp-Gly-Cys-Glu-Leu
InChIKey: WFZPJYYCTSHDJI-KMTCJHMQNA-N
SMILES: [C@H](CCC(=O)O)(C(=O)N[C@H](C(=O)O)CC(C)C)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC=O)CCSC |&1:0,9,20,30,38,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5461
Product name: Foxy5
Packaging: 1
Price: $151
Updated: 2021/12/16

TRC

Product number: F746003
Product name: Foxy5Discontinued(seeF746005)
Packaging: 1mg
Price: $135
Updated: 2021/12/16

Usbiological

Product number: 255329
Product name: Foxy 5
Packaging: 1mg
Price: $389
Updated: 2021/12/16

DC Chemicals

Product number: DC23893
Product name: Foxy-5(Wnt5apeptidemimetic)
Purity: >98%
Packaging: 10mg
Price: $400
Updated: 2021/12/16

DC Chemicals

Product number: DC23893
Product name: Foxy-5(Wnt5apeptidemimetic)
Purity: >98%
Packaging: 25mg
Price: $650
Updated: 2021/12/16

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FOXY-5 Chemical Properties,Usage,Production

Uses

Foxy 5 is a Wnt-5a-derived hexapeptide, which inhibits breast cancer metastasis in vivo by targeting cell motility.

Definition

ChEBI: (2S)-2-[[(2S)-4-carboxy-2-[[(2R)-2-[[2-[[(2S)-3-carboxy-2-[[(2S)-2-formamido-4-(methylthio)-1-oxobutyl]amino]-1-oxopropyl]amino]-1-oxoethyl]amino]-3-mercapto-1-oxopropyl]amino]-1-oxobutyl]amino]-4-methylpentanoic acid is a peptide.

in vivo

Foxy-5 (2 mg/kg intraperitoneally injected 9 times a day for 7-23 days) reduces the number of colon cancer stem cells in a mouse model of human colon cancer xenotransplantation^[2].
Foxy-5 (2 mg/kg, intraperitoneal injection, once a day, for 3-9 weeks) significantly reduces the early metastasis and spread of WNT5A low DU145 prostate cancer cells in a mouse model of prostate cancer xenotransplantation^[3].

Animal Model:	A Xenograft Mouse Model of Human Colonic Cancer^[2]
Dosage:	2 mg/kg
Administration:	i.p. 9 times a day for 7-23 days
Result:	Reduced the expression of ALDH, DCLK1 and COX-2. Increased the expression of 15-PGDH. Reduced the expression of the downstream β-catenin target ASCL2.

Animal Model:	A Xenograft Mouse Model of Prostate Cancer ^[3]
Dosage:	2 mg/kg
Administration:	i.p. once a day, for 3-9 weeks
Result:	Reduced metastatic spread and the number of tumor cells in lymph nodes.

storage

Store at -20°C

FOXY-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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FOXY-5 Suppliers

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View Lastest Price from FOXY-5 manufacturers

BOC Sciences

Product: Foxy-5 881188-51-8
Price: US $0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1kg
Release date: 2020-05-15

881188-51-8, FOXY-5Related Search:

L-Glutamine

FOXY-5

N-formyl-L-methionyl-L-alpha-aspartyl-glycyl-L-cysteinyl-L-alpha-glutamyl-L-leucine

L-Leucine, N-formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl-

Foxy-5(Wnt5a peptide mimetic)

Foxy 5 Discontinued (see F746005)

(2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecane-1,16-dioic acid

Foxy 5 trifluoroacetic acid

Foxy-5 ，S6961

(2S,5S,8R,14S)-5-(2-Carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butancarboxcarboxcarboxamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecan-1,16-dioic acid

881188-51-8

C26H42N6O12S2