Elacestrant dihydrochloride

Product Name: Elacestrant dihydrochloride
CAS No.: 1349723-93-8
Chemical Name: Elacestrant dihydrochloride
Synonyms: RAD-1901;RAD1901 2HCl;RAD-1901 2HCl;RAD 1901 2HCl;Elacestrant HCl;Elacestrant 2HCl;RAD1901 HCl salt;Elacestrant DiHCl;RAD1901 dihydrochloride;Elacestrant dihydrochloride
CBNumber: CB53145541
Molecular Formula: C30H40Cl2N2O2
Formula Weight: 531.5568
MOL File: 1349723-93-8.mol

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Elacestrant dihydrochloride Property

solubility: DMSO:100.0(Max Conc. mg/mL);188.13(Max Conc. mM)
H2O:50.0(Max Conc. mg/mL);94.06(Max Conc. mM)
form: Solid
color: White to off-white
InChIKey: TVTRJGWMKDMZSN-AAZDGHFONA-N
SMILES: N(C1C=C(OC)C=CC=1[C@@H]1CCC2=CC(O)=CC=C2C1)(CC)CC1C=CC(CCNCC)=CC=1.Cl |&1:9,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC10182
Product name: Elacestrantdihydrochloride
Purity: >98%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC10182
Product name: Elacestrantdihydrochloride
Purity: >98%
Packaging: 1g
Price: $3600
Updated: 2021/12/16

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Elacestrant dihydrochloride Chemical Properties,Usage,Production

Uses

Elacestrant (RAD1901) dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant dihydrochloride also can inhibit growth of ER+ breast cancer cell lines in vitro and in vivo[1][2].

in vivo

Elacestrant dihydrochloride (0.3-120 mg/kg; p.o.; single daily for 40 days) antagonizes E2-mediated uterine stimulation in a dose-dependent manner in vivo^[1].
Elacestrant dihydrochloride (30, 60 mg/kg; p.o.; single daily for 4 weeks) induces complete tumor growth inhibition in mice^[2].
Tumor growth inhibition is maintained for 4 weeks after Elacestrant dihydrochloride withdrawal^[2].

Animal Model:	MCF7 cell line xenograft model of mice^[2].
Dosage:	30, 60 mg/kg
Administration:	Oral administration; single daily for 4 weeks.
Result:	Inhibited growth of tumor.

References

[1] Garner F, et al. RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models. Anticancer Drugs. 2015 Oct;26(9):948-56. DOI:10.1097/CAD.0000000000000271
[2] Bihani T, et al. Elacestrant (RAD1901), a Selective Estrogen Receptor Degrader (SERD), Has Antitumor Activity in Multiple ER+ Breast Cancer Patient-derived Xenograft Models. Clin Cancer Res. 2017 Aug 15;23(16):4793-4804. DOI:10.1158/1078-0432.CCR-16-2561

Elacestrant dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Elacestrant dihydrochloride Suppliers

China 93 United States 4 Global 97

Hangzhou Hua Zhe Biological Medicine Co., LTD

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View Lastest Price from Elacestrant dihydrochloride manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Elacestrant Dihydrochloride 956104-93-8
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2025-09-09

Guangzhou Weiaokang Pharmaceutical Technology Co., Ltd

Product: Elacestrant dihydrochloride，PhEur/USP(DMF) 1349723-93-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2025-08-05

1349723-93-8, Elacestrant dihydrochlorideRelated Search:

Fulvestrant β-Estradiol Elacestrant 2-Naphthalenol, 6-(2-amino-4-methoxyphenyl)-5,6,7,8-tetrahydro-, (6R)- Acetamide, N-[2-[3,4-dihydro-6-(phenylmethoxy)-2-naphthalenyl]-5-methoxyphenyl]- Acetamide, N-[5-methoxy-2-(1,2,3,4-tetrahydro-6-hydroxy-2-naphthalenyl)phenyl]-

Elacestrant dihydrochloride

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RAD1901 HCl salt

(6R)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol dihydrochloride

Elacestrant 2HCl

RAD-1901

RAD1901 dihydrochloride

RAD 1901 2HCl

RAD1901 2HCl

RAD-1901 2HCl

2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, hydrochloride (1:2), (6R)-

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RAD 1901,inhibit,RAD-1901,Inhibitor,Elacestrant,Estrogen Receptor/ERR,RAD1901,Elacestrant dihydrochloride

Elacestrant (RAD1901) Dihydrochloride

Elacestrant HCl

Elacestrant dihydrochloride, 10 mM in DMSO

Elacestrant DiHCl

Elacestrant dihydrochloride，PhEur/USP(DMF)

1349723-93-8

956104-93-8

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