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Elacestrant

Product Name
Elacestrant
CAS No.
722533-56-4
Chemical Name
Elacestrant
Synonyms
Elacestrant;Elacestrant (RAD1901);Venadaparib Impurity 54;Elacestrant, 10 mM in DMSO;Elacestrant - API standards;Elacestrant ISO 9001：2015 REACH;inhibit,RAD 1901,Estrogen Receptor/ERR,Inhibitor,Elacestrant,RAD-1901;(R)-6-[2-[Ethyl[4-[2-(ethylamino)ethyl]benzyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol;(6R)-6-2-ethyl(4-2-(ethylamino)ethylphenylmethyl)amino-4-methoxyphenyl-5,6,7,8-tetrahydronaphthalen-2-ol;2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, (6R)-
CBNumber
CB63167609
Molecular Formula
C30H38N2O2
Formula Weight
458.63
MOL File
722533-56-4.mol
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Elacestrant Property

Boiling point:
609.5±55.0 °C(Predicted)
Density 
1.111±0.06 g/cm3(Predicted)
pka
10.36±0.40(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1S/C30H38N2O2/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3/t26-/m1/s1
InChIKey
SIFNOOUKXBRGGB-AREMUKBSSA-N
SMILES
C1=C2C(C[C@H](C3=CC=C(OC)C=C3N(CC)CC3=CC=C(CCNCC)C=C3)CC2)=CC=C1O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb611458
Product name
Elacestrant
Packaging
5mg
Price
$569.5
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611458
Product name
Elacestrant
Packaging
10mg
Price
$615.4
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611458
Product name
Elacestrant
Packaging
50mg
Price
$1802
Updated
2021/12/16
DC Chemicals
Product number
DC22559
Product name
Elacestrant
Purity
>98%
Packaging
5mg
Price
$280
Updated
2021/12/16
DC Chemicals
Product number
DC22559
Product name
Elacestrant
Purity
>98%
Packaging
10mg
Price
$400
Updated
2021/12/16
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Elacestrant Chemical Properties,Usage,Production

Uses

Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER+ breast cancer cell lines in vitro and in vivo[1][2].

in vivo

Elacestrant (0.3-120 mg/kg; p.o.; single daily for 40 days) antagonizes E2-mediated uterine stimulation in a dose-dependent manner in vivo[1].
Elacestrant (30, 60 mg/kg; p.o.; single daily for 4 weeks) induces complete tumor growth inhibition in mice[2].
Tumor growth inhibition is maintained for 4 weeks after Elacestrant withdrawal[2].

Animal Model:MCF7 cell line xenograft model of mice[2].
Dosage:30, 60 mg/kg
Administration:Oral administration; single daily for 4 weeks.
Result:Inhibited growth of tumor.

References

[1] Garner F, et al. RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models. Anticancer Drugs. 2015 Oct;26(9):948-56. DOI:10.1097/CAD.0000000000000271
[2] Bihani T, et al. Elacestrant (RAD1901), a Selective Estrogen Receptor Degrader (SERD), Has Antitumor Activity in Multiple ER+ Breast Cancer Patient-derived Xenograft Models. Clin Cancer Res. 2017 Aug 15;23(16):4793-4804. DOI:10.1158/1078-0432.CCR-16-2561

Elacestrant Preparation Products And Raw materials

Raw materials

Preparation Products

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Elacestrant Suppliers

China 78 India 2 United States 5 USA 1 Global 86
HANGZHOU YOUHELIN PHARMTECH CO.LTD
Tel
18268150871; 17302275155
Email
tanglulu11129@163.com
Country
China
ProdList
28
Advantage
58
Hangzhou Chemtrue Bio-Tech Co.,Ltd.
Tel
0571-86828652 18857119830
Fax
0571-83522824
Email
sales@chemtrue-bio.com
Country
China
ProdList
252
Advantage
58
Arizest(Shanghai)Pharmatech Co.,Ltd
Tel
13671599112
Email
geshi.zhuang@synovent.cn
Country
China
ProdList
426
Advantage
58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-02136680027 15800370750
Email
1706640024@qq.com
Country
China
ProdList
570
Advantage
56
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55

722533-56-4, ElacestrantRelated Search:

Fulvestrant ESTETROL β-Estradiol Elacestrant dihydrochloride 2-Naphthalenol, 6-(2-amino-4-methoxyphenyl)-5,6,7,8-tetrahydro-, (6R)- Acetamide, N-[2-[3,4-dihydro-6-(phenylmethoxy)-2-naphthalenyl]-5-methoxyphenyl]- Acetamide, N-[5-methoxy-2-(1,2,3,4-tetrahydro-6-hydroxy-2-naphthalenyl)phenyl]-

  • Elacestrant
  • Elacestrant (RAD1901)
  • 2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, (6R)-
  • Elacestrant ISO 9001：2015 REACH
  • inhibit,RAD 1901,Estrogen Receptor/ERR,Inhibitor,Elacestrant,RAD-1901
  • (6R)-6-2-ethyl(4-2-(ethylamino)ethylphenylmethyl)amino-4-methoxyphenyl-5,6,7,8-tetrahydronaphthalen-2-ol
  • (R)-6-[2-[Ethyl[4-[2-(ethylamino)ethyl]benzyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
  • Venadaparib Impurity 54
  • Elacestrant - API standards
  • Elacestrant, 10 mM in DMSO
  • (6R)-6-{2-[Ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol. dihydrochloride
  • 722533-56-4
  • 22533-56-4
  • API