ChemicalBook > CAS DataBase List > Elacestrant

Elacestrant

Product Name: Elacestrant
CAS No.: 722533-56-4
Chemical Name: Elacestrant
Synonyms: Elacestrant;Elacestrant (RAD1901);Venadaparib Impurity 54;Elacestrant, 10 mM in DMSO;Elacestrant - API standards;Elacestrant ISO 9001：2015 REACH;inhibit,RAD 1901,Estrogen Receptor/ERR,Inhibitor,Elacestrant,RAD-1901;(R)-6-[2-[Ethyl[4-[2-(ethylamino)ethyl]benzyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol;(6R)-6-2-ethyl(4-2-(ethylamino)ethylphenylmethyl)amino-4-methoxyphenyl-5,6,7,8-tetrahydronaphthalen-2-ol;2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, (6R)-
CBNumber: CB63167609
Molecular Formula: C30H38N2O2
Formula Weight: 458.63
MOL File: 722533-56-4.mol

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Elacestrant Property

Boiling point:: 609.5±55.0 °C(Predicted)
Density: 1.111±0.06 g/cm3(Predicted)
pka: 10.36±0.40(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C30H38N2O2/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3/t26-/m1/s1
InChIKey: SIFNOOUKXBRGGB-AREMUKBSSA-N
SMILES: C1=C2C(C[C@H](C3=CC=C(OC)C=C3N(CC)CC3=CC=C(CCNCC)C=C3)CC2)=CC=C1O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611458
Product name: Elacestrant
Packaging: 5mg
Price: $569.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611458
Product name: Elacestrant
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611458
Product name: Elacestrant
Packaging: 50mg
Price: $1802
Updated: 2021/12/16

DC Chemicals

Product number: DC22559
Product name: Elacestrant
Purity: >98%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

DC Chemicals

Product number: DC22559
Product name: Elacestrant
Purity: >98%
Packaging: 10mg
Price: $400
Updated: 2021/12/16

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Elacestrant Chemical Properties,Usage,Production

Uses

Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER+ breast cancer cell lines in vitro and in vivo[1][2].

in vivo

Elacestrant (0.3-120 mg/kg; p.o.; single daily for 40 days) antagonizes E2-mediated uterine stimulation in a dose-dependent manner in vivo^[1].
Elacestrant (30, 60 mg/kg; p.o.; single daily for 4 weeks) induces complete tumor growth inhibition in mice^[2].
Tumor growth inhibition is maintained for 4 weeks after Elacestrant withdrawal^[2].

Animal Model:	MCF7 cell line xenograft model of mice^[2].
Dosage:	30, 60 mg/kg
Administration:	Oral administration; single daily for 4 weeks.
Result:	Inhibited growth of tumor.

References

[1] Garner F, et al. RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models. Anticancer Drugs. 2015 Oct;26(9):948-56. DOI:10.1097/CAD.0000000000000271
[2] Bihani T, et al. Elacestrant (RAD1901), a Selective Estrogen Receptor Degrader (SERD), Has Antitumor Activity in Multiple ER+ Breast Cancer Patient-derived Xenograft Models. Clin Cancer Res. 2017 Aug 15;23(16):4793-4804. DOI:10.1158/1078-0432.CCR-16-2561

Elacestrant Preparation Products And Raw materials

Raw materials

Preparation Products

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Elacestrant Suppliers

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722533-56-4, ElacestrantRelated Search:

Fulvestrant ESTETROL β-Estradiol Elacestrant dihydrochloride 2-Naphthalenol, 6-(2-amino-4-methoxyphenyl)-5,6,7,8-tetrahydro-, (6R)- Acetamide, N-[2-[3,4-dihydro-6-(phenylmethoxy)-2-naphthalenyl]-5-methoxyphenyl]- Acetamide, N-[5-methoxy-2-(1,2,3,4-tetrahydro-6-hydroxy-2-naphthalenyl)phenyl]-

Elacestrant

Elacestrant (RAD1901)

2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, (6R)-

Elacestrant ISO 9001：2015 REACH

inhibit,RAD 1901,Estrogen Receptor/ERR,Inhibitor,Elacestrant,RAD-1901

(6R)-6-2-ethyl(4-2-(ethylamino)ethylphenylmethyl)amino-4-methoxyphenyl-5,6,7,8-tetrahydronaphthalen-2-ol

(R)-6-[2-[Ethyl[4-[2-(ethylamino)ethyl]benzyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol

Venadaparib Impurity 54

Elacestrant - API standards

Elacestrant, 10 mM in DMSO

(6R)-6-{2-[Ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol. dihydrochloride

722533-56-4

22533-56-4

API