ChemicalBook > CAS DataBase List > SHP-627

SHP-627

Product Name
SHP-627
CAS No.
1001288-58-9
Chemical Name
SHP-627
Synonyms
FT011;SHP-627;asengeprast;FT011;SHP-627;FT011, 10 mM in DMSO;Inhibitor,FT011,FT 011,inhibit,FT-011;(E)-2-(3-(3-Methoxy-4-(prop-2-yn-1-yloxy)phenyl)acrylamido)benzoic acid;2-[[(E)-3-(3-methoxy-4-prop-2-ynoxyphenyl)prop-2-enoyl]amino]benzoic acid;(E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid;Benzoic acid, 2-[[(2E)-3-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]-1-oxo-2-propen-1-yl]amino]-
CBNumber
CB53145905
Molecular Formula
C20H17NO5
Formula Weight
351.35
MOL File
1001288-58-9.mol
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SHP-627 Property

Boiling point:
618.9±55.0 °C(Predicted)
Density 
1.307±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 29 mg/mL (82.54 mM)
form 
Solid
pka
3.45±0.36(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
F810410
Product name
(E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoicAcid
Packaging
0.5mg
Price
$65
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611486
Product name
FT-011
Packaging
5mg
Price
$324.7
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611486
Product name
FT-011
Packaging
10mg
Price
$399.5
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611486
Product name
FT-011
Packaging
50mg
Price
$1101.6
Updated
2021/12/16
DC Chemicals
Product number
DC22587
Product name
FT011
Purity
>98%
Packaging
100mg
Price
$600
Updated
2021/12/16
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SHP-627 Chemical Properties,Usage,Production

Uses

FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis[1]. FT011 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats[1].

Animal Model:Seventy male Sprague Dawley (SD) rats (weighing 200-250 g)[1]
Dosage:100 mg/kg
Administration:B.I.D., p.o. on day 7 after surgery, for 4 weeks
Result:Increased ejection fraction, fraction shortening and preload recruitable stroke work.

SHP-627 Preparation Products And Raw materials

Raw materials

Preparation Products

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SHP-627 Suppliers

China 57 United States 6 Global 63
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1001288-58-9, SHP-627Related Search:


  • SHP-627
  • FT011
  • FT011;SHP-627
  • Benzoic acid, 2-[[(2E)-3-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]-1-oxo-2-propen-1-yl]amino]-
  • (E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid
  • (E)-2-(3-(3-Methoxy-4-(prop-2-yn-1-yloxy)phenyl)acrylamido)benzoic acid
  • Inhibitor,FT011,FT 011,inhibit,FT-011
  • asengeprast
  • FT011, 10 mM in DMSO
  • 2-[[(E)-3-(3-methoxy-4-prop-2-ynoxyphenyl)prop-2-enoyl]amino]benzoic acid
  • 1001288-58-9