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PGD2-inhibitor

Product Name
PGD2-inhibitor
CAS No.
885066-67-1
Chemical Name
PGD2-inhibitor
Synonyms
MDK66671;PGD2-IN-1;PGD2-inhibitor;PGD2 inhibitor 1;PGD2-IN-1?, >98%;PGD2-inhibitor, >98%;PGD2-IN-1, 10 mM in DMSO;prostaglandin D2(PGD2) inhibitor;2-[3-(6-{[2-(2,4-dichlorophenyl)ethyl]amino}-2-methoxypyrimidin-4-yl)phenyl]-2-methylpropanoic acid;Benzeneacetic acid, 3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl-
CBNumber
CB53146427
Molecular Formula
C23H23Cl2N3O3
Formula Weight
460.35
MOL File
885066-67-1.mol
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PGD2-inhibitor Property

Boiling point:
682.1±65.0 °C(Predicted)
Density 
1.326±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 25 mg/mL (54.31 mM)
form 
Solid
pka
4.09±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC9867
Product name
prostaglandinD2(PGD2)inhibitor
Purity
>98%
Packaging
10mg
Price
$300
Updated
2021/12/16
DC Chemicals
Product number
DC9867
Product name
prostaglandinD2(PGD2)inhibitor
Purity
>98%
Packaging
25mg
Price
$450
Updated
2021/12/16
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PGD2-inhibitor Chemical Properties,Usage,Production

Biological Activity

PGD2-IN-1 is a DP receptor antagonist from patent patent WO 2006044732 A2, compound example 15 (d) with IC50 value of 0.3 nM.

in vitro

Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists has been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically has been shown to inhibit the antigen-induced nasal congestion.

target

IC50: 0.3 nM

PGD2-inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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885066-67-1, PGD2-inhibitorRelated Search:


  • PGD2-inhibitor
  • PGD2-IN-1
  • MDK66671
  • PGD2-IN-1?, >98%
  • PGD2-inhibitor, >98%
  • prostaglandin D2(PGD2) inhibitor
  • PGD2 inhibitor 1
  • Benzeneacetic acid, 3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl-
  • Benzeneacetic acid, 3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl-
  • 2-[3-(6-{[2-(2,4-dichlorophenyl)ethyl]amino}-2-methoxypyrimidin-4-yl)phenyl]-2-methylpropanoic acid
  • PGD2-IN-1, 10 mM in DMSO
  • 885066-67-1