ChemicalBook > CAS DataBase List > PGD2-inhibitor

PGD2-inhibitor

Product Name: PGD2-inhibitor
CAS No.: 885066-67-1
Chemical Name: PGD2-inhibitor
Synonyms: MDK66671;PGD2-IN-1;PGD2-inhibitor;PGD2 inhibitor 1;PGD2-IN-1?, >98%;PGD2-inhibitor, >98%;PGD2-IN-1, 10 mM in DMSO;Prostaglandin D2 Inhibitor;prostaglandin D2(PGD2) inhibitor;2-[3-(6-{[2-(2,4-dichlorophenyl)ethyl]amino}-2-methoxypyrimidin-4-yl)phenyl]-2-methylpropanoic acid
CBNumber: CB53146427
Molecular Formula: C23H23Cl2N3O3
Formula Weight: 460.35
MOL File: 885066-67-1.mol

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PGD2-inhibitor Property

Boiling point:: 682.1±65.0 °C(Predicted)
Density: 1.326±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 25 mg/mL (54.31 mM)
form: Solid
pka: 4.09±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC9867
Product name: prostaglandinD2（PGD2)inhibitor
Purity: >98%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

DC Chemicals

Product number: DC9867
Product name: prostaglandinD2（PGD2)inhibitor
Purity: >98%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

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PGD2-inhibitor Chemical Properties,Usage,Production

Uses

PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.

Biological Activity

PGD2-IN-1 is a DP receptor antagonist from patent patent WO 2006044732 A2, compound example 15 (d) with IC50 value of 0.3 nM.

in vitro

Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists has been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically has been shown to inhibit the antigen-induced nasal congestion.

target

IC50: 0.3 nM

References

[1] Lim, Sungtaek, et al. 2, 6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS. WO2006044732A2.
[2] Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75. DOI:10.1016/j.bmcl.2010.11.071

PGD2-inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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885066-67-1, PGD2-inhibitorRelated Search:

PGD2-inhibitor

PGD2-IN-1

MDK66671

PGD2-IN-1?, >98%

PGD2-inhibitor, >98%

prostaglandin D2(PGD2) inhibitor

PGD2 inhibitor 1

Benzeneacetic acid, 3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl-

2-[3-(6-{[2-(2,4-dichlorophenyl)ethyl]amino}-2-methoxypyrimidin-4-yl)phenyl]-2-methylpropanoic acid

PGD2-IN-1, 10 mM in DMSO

Prostaglandin D2 Inhibitor

885066-67-1