ChemicalBook > CAS DataBase List > PGD2-inhibitor
PGD2-inhibitor
- Product Name
- PGD2-inhibitor
- CAS No.
- 885066-67-1
- Chemical Name
- PGD2-inhibitor
- Synonyms
- MDK66671;PGD2-IN-1;PGD2-inhibitor;PGD2 inhibitor 1;PGD2-IN-1?, >98%;PGD2-inhibitor, >98%;PGD2-IN-1, 10 mM in DMSO;prostaglandin D2(PGD2) inhibitor;2-[3-(6-{[2-(2,4-dichlorophenyl)ethyl]amino}-2-methoxypyrimidin-4-yl)phenyl]-2-methylpropanoic acid;Benzeneacetic acid, 3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl-
- CBNumber
- CB53146427
- Molecular Formula
- C23H23Cl2N3O3
- Formula Weight
- 460.35
- MOL File
- 885066-67-1.mol
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PGD2-inhibitor Property
- Boiling point:
- 682.1±65.0 °C(Predicted)
- Density
- 1.326±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 25 mg/mL (54.31 mM)
- form
- Solid
- pka
- 4.09±0.10(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- DC9867
- Product name
- prostaglandinD2（PGD2)inhibitor
- Purity
- >98%
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC9867
- Product name
- prostaglandinD2（PGD2)inhibitor
- Purity
- >98%
- Packaging
- 25mg
- Price
- $450
- Updated
- 2021/12/16
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PGD2-inhibitor Chemical Properties,Usage,Production
Biological Activity
PGD2-IN-1 is a DP receptor antagonist from patent patent WO 2006044732 A2, compound example 15 (d) with IC50 value of 0.3 nM.
in vitro
Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists has been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically has been shown to inhibit the antigen-induced nasal congestion.
target
IC50: 0.3 nM
PGD2-inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
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