N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide

Product Name: N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide
CAS No.: 869199-61-1
Chemical Name: N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide
Synonyms: N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4...;N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide;Acetamide, N-(3-chloro-4-fluorophenyl)-N-(7-methoxy-6-nitro-4-quinazolinyl)-;N-(3-chloro-4-fluoro-phenyl)-N-(7-methoxy-6-nitro-quinazoline-4-yl)-acetamide
CBNumber: CB53151687
Molecular Formula: C17H12ClFN4O4
Formula Weight: 390.75
MOL File: 869199-61-1.mol

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N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide Property

storage temp.: Sealed in dry,Room Temperature

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 4504DP
Product name: N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide
Packaging: 250mg
Price: $88
Updated: 2021/12/16

Ambeed

Product number: A264645
Product name: N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide
Purity: 97%
Packaging: 250mg
Price: $9
Updated: 2021/12/16

Ambeed

Product number: A264645
Product name: N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide
Purity: 97%
Packaging: 1g
Price: $22
Updated: 2021/12/16

Ambeed

Product number: A264645
Product name: N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide
Purity: 97%
Packaging: 5g
Price: $73
Updated: 2021/12/16

Alichem

Product number: 869199611
Product name: N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide
Packaging: 1g
Price: $198
Updated: 2021/12/16

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N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide Chemical Properties,Usage,Production

Synthesis

179552-74-0

108-24-7

869199-61-1

General procedure for the synthesis of N-(3-chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide from N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine and acetic anhydride: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine (17.26 g, 0.0495 mol) was suspended in 350 ml of acetic anhydride under nitrogen protection, heated to 90 °C and maintained for 24 hours. After completion of the reaction, it was slowly cooled to room temperature to form a light colored suspension. Cooling was continued to 0 °C and maintained for 1 hour. The solid was collected by filtration and the flask and filter cake were washed with 2 x 50 ml isopropanol. The product, N-(3-chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide, was dried in a vacuum oven at 60 °C for 24 h to give 17.97 g (92.4% yield).HPLC analysis showed purity of 99.45% and retention time of 13.705 min. Raney Ni (5.0 g) was made into a suspension in methanol followed by displacement of water with tetrahydrofuran. N-(3-chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide (19.2 g, 49 mmol) was suspended in 500 ml of tetrahydrofuran and added to the reactor. It was heated to 60 °C and pressurized to 60 psi hydrogen pressure. After about 17 hours of reaction, 10.0 g of catalyst was added and the reaction was continued for 38 hours. Upon completion of the reaction, it was filtered and washed with tetrahydrofuran. The filtrate was concentrated and the solvent was replaced with hexane. Upon addition of hexane, a light yellow solid precipitated. The solvent was removed under vacuum and the residual tetrahydrofuran was removed by distillation. The filtrate was filtered and washed with a large amount of hexane. The product N-(6-amino-7-methoxyquinazolin-4-yl)-N-(3-chloro-4-fluorophenyl)acetamide was dried in a vacuum oven at 70 °C for 24 h to give 16.75 g (94.49% yield). HPLC analysis showed 100% purity. Oxoallyl chloride was added to a 40 ml dichloromethane solution containing 60 mg of 4-piperidin-1-yl-but-2-enoic acid at room temperature and stirred for 1 hour. The solvent was evaporated under vacuum and the resulting solid was suspended in 150 ml of dimethylacetamide. To the reaction mixture was added solid N-(6-amino-7-methoxyquinazolin-4-yl)-N-(3-chloro-4-fluorophenyl)acetamide. The reaction was completed after 45 minutes. The mixture was added slowly dropwise to 300 ml of 2N sodium hydroxide solution and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, concentrated to 100 ml and stirred at room temperature for 2 days. 300 ml of ether and 100 ml of 2N sodium hydroxide were added and the precipitated solid was collected by filtration. The final product was recrystallized with vinyl chloride to give 5.5 g of pure product.

References

[1] Patent: US2005/250761, 2005, A1. Location in patent: Page/Page column 18-20

N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide Preparation Products And Raw materials

Raw materials

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N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide Suppliers

China 28 India 1 United States 1 Global 30

Hunan Hui Bai Shi Biotechnology Co., Ltd.

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Jinan SanZhi Pharmaceutical Technology Co., Ltd.

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Amadis Chemical Company Limited

Tel: 571-89925085
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Aikon International Limited

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Hebei Yanxi Chemical Co., Ltd.

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Hefei TNJ Chemical Industry Co.,Ltd.

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Baoji Guokang Healthchem Co., Ltd.

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Neostar United (Changzhou) Industrial Co., Ltd.

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Shanghai Botuo Biotechnology Co., LTD

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Energy Chemical

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View Lastest Price from N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide 869199-61-1
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-05

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-(3-chloro-4-fluoro-phenyl)-N-(7-methoxy-6-nitro-quinazoline-4-yl)-acetamide 869199-61-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-(3-chloro-4-fluoro-phenyl)-N-(7-methoxy-6-nitro-quinazoline-4-yl)-acetamide 869199-61-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

869199-61-1, N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamideRelated Search:

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N-(3-chloro-4-fluoro-phenyl)-N-(7-methoxy-6-nitro-quinazoline-4-yl)-acetamide

N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4...

869199-61-1