R-7050
- Product Name
- R-7050
- CAS No.
- 303997-35-5
- Chemical Name
- R-7050
- Synonyms
- R-7050;R-7050;R 7050;R7050;TNF-α Antagonist III;TNF-α Antagonist III;TNF-alpha Antagonist III, R-7050;8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline;[1,2,4]Triazolo[4,3-a]quinoxaline, 8-chloro-4-(phenylthio)-1-(trifluoromethyl)-;R 7050,Inhibitor,R7050,inhibit,TNFR,Tumor Necrosis Factor Receptor,TNF Receptor,R-7050
- CBNumber
- CB53152725
- Molecular Formula
- C16H8ClF3N4S
- Formula Weight
- 380.77
- MOL File
- 303997-35-5.mol
R-7050 Property
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- insoluble in H2O; ≥17.67 mg/mL in DMSO; ≥2.2 mg/mL in EtOH with gentle warming and ultrasonic
- form
- crystalline solid
- pka
- -3.70±0.30(Predicted)
N-Bromosuccinimide Price
- Product number
- 654257
- Product name
- TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem
- Packaging
- 10mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- 16870
- Product name
- R-7050
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16870
- Product name
- R-7050
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 16870
- Product name
- R-7050
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 16870
- Product name
- R-7050
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $305
- Updated
- 2024/03/01
R-7050 Chemical Properties,Usage,Production
Uses
R 7050 is a cell permeable TNF-α receptor antagonist.
Biological Activity
ec50: 0.631 μm by tnf-α by icam-1 elisa assayr-7050 is a tnf-α receptor signaling antagonist.tnf-α induces biological activity throgh stimulation of the tumor necrosis factor receptor. although plenty of pre-clinical and clinical evidence suggests a detrimental role, small molecule tnf-αsignaling pathway inhibitors remain largely unexplored in the context of a brain hemorrhage.
in vitro
r-7050 was identified as a selective inhibitot of tnf-α induced cellular signaling by using differential library screening. unlike biologic tnf inhibitors directly binding tnf-α, r-7050 could not affect binding of tnf-α to tnfr. in contrast, r-7050 was able to selectively inhibit the association of tnf receptor with intracellular adaptor molecules [1].
in vivo
in previous animal study, r-7050 was tested to attenuate neurovascular injury after intracerebral hemorrhage (ich) in mice. results showed that up to 2h post-injury administration of r-7050 was able to significantly reduce blood-brain barrier opening and attenuate edema development at 24h post-ich. in addition, neurological outcomes were also improved over the first 3 days after injury. whereas, r-7050 was not found to be albe to reduce hematoma volume, indicating the beneficial effects of tnfr inhibition were downstream of clot formation/resolution [2].
storage
Store at +4°C
References
[1] gururaja tl, yung s, ding r, huang j, zhou x, mclaughlin j, daniel-issakani s, singh r, cooper rd, payan dg, masuda es, kinoshita t. a class of small molecules that inhibit tnfalpha-induced survival and death pathways via prevention of interactions between tnfalphari, tradd, and rip1. chem biol. 2007 oct;14(10):1105-18.
[2] king md, alleyne ch jr, dhandapani km. tnf-alpha receptor antagonist, r-7050, improves neurological outcomes following intracerebral hemorrhage in mice. neurosci lett. 2013 may 10;542:92-6.
R-7050 Preparation Products And Raw materials
Raw materials
Preparation Products
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