ChemicalBook > CAS DataBase List > Vps

Vps

Product Name: Vps
CAS No.: 1383716-46-8
Chemical Name: Vps
Synonyms: Compound 19;Vps;VPS34-IN-19;PIK-III analogue;VPS34 inhibitor 1;Compound 19, PIK-III analogue;VPS34 inhibitor 1 (Compound 19);VPS34 inhibitor 1 (PIK-III analogue);VPS34 inhibitor 1 (Compound 19, PIK-III analogue);VPS34 inhibitor 1 (Compound 19, PIK-III analogue), 10 mM in DMSO
CBNumber: CB53158772
Molecular Formula: C21H25N7O
Formula Weight: 391.47
MOL File: 1383716-46-8.mol

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Vps Property

Boiling point:: 676.1±65.0 °C(Predicted)
Density: 1.324±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 78 mg/mL (199.25 mM);Ethanol: Insoluble
pka: 14.68±0.29(Predicted)
form: Solid
color: White to off-white
Water Solubility: Water: Insoluble

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C990250
Product name: 1-[[4''-(Cyclopropylmethyl)-2-(4-pyridinylamino)[4,5''-bipyrimidin]-2''-yl]amino]-2-methyl-2-propanol
Packaging: 5mg
Price: $200
Updated: 2021/12/16

Crysdot

Product number: CD31004929
Product name: VPS34inhibitor1
Purity: 95%
Packaging: 10mg
Price: $309
Updated: 2021/12/16

DC Chemicals

Product number: DC10019
Product name: VPS34inhibitor1(Compound19,PIK-IIIanalogue)
Purity: >98%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

Crysdot

Product number: CD31004929
Product name: VPS34inhibitor1
Purity: 95%
Packaging: 25mg
Price: $527
Updated: 2021/12/16

DC Chemicals

Product number: DC10019
Product name: VPS34inhibitor1(Compound19,PIK-IIIanalogue)
Purity: >98%
Packaging: 50mg
Price: $900
Updated: 2021/12/16

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Vps Chemical Properties,Usage,Production

Uses

1-?[[4''-?(Cyclopropylmethyl)?-?2-?(4-?pyridinylamino)?[4,?5''-?bipyrimidin]?-?2''-?yl]?amino]?-?2-?methyl-2-?propanol is a selective PI 3-?kinase VPS34 inhibitor. VPS34 inhibitors can be used to investigate autophagy, a degradation process that recycles cellular components.

Synthesis

1383716-87-7

44838-96-2

1383716-46-8

Synthesis of 1-((4'-(cyclopropylmethyl)-2-(pyridin-4-ylamino)-[4,5'-bipyridin]-2'-yl)amino)-2-methylpropan-2-ol (1 Ot): a new synthesis of 1-((4'-(cyclopropylmethyl)-2-(pyridin-4-ylamino)-[4,5'-bipyridin]-2'-yl)amino)-2-methylpropan-2-ol (1 Ot) was carried out by adding a new synthesizer to the (Z)-1-cyclopropyl-4-(dimethylamino)-3-(2-( pyridin-4-ylamino)pyrimidin-4-yl)but-3-en-2-one (9) (50 mg, 0.155 mmol) was added to a solution of 1-(2-hydroxy-2-methylpropyl)guanidine and potassium carbonate (107 mg, 0.773 mmol) in DMF (1288 μL). The reaction mixture was stirred at 120 °C for 2 hours. Upon completion of the reaction, the crude product was purified by reversed-phase HPLC (gradient: 30-90% organic phase, 15 min), followed by further purification using Biotage? silica gel chromatography (10 g SNAP column, elution gradient: 100% DCM to 12% MeOH/DCM) to afford the target product (23.8 mg, 39% yield).

References

[1] Patent: WO2012/85815, 2012, A1. Location in patent: Page/Page column 65-66
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 1, p. 72 - 76

Vps Preparation Products And Raw materials

Raw materials

Preparation Products

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Vps Suppliers

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1383716-46-8, VpsRelated Search:

VS-5584 VR23 VRT752271

Vps

1-((4'-(cyclopropylmethyl)-2-(pyridin-4-ylamino)-[4,5'-bipyrimidin]-2'-yl)amino)-2-methylpropan-2-ol

VPS34 inhibitor 1

VPS34 inhibitor 1 (Compound 19, PIK-III analogue)

Compound 19, PIK-III analogue

Compound 19

PIK-III analogue

VPS34 inhibitor 1 (PIK-III analogue)

2-Propanol, 1-[[4'-(cyclopropylmethyl)-2-(4-pyridinylamino)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-

1-?[[4'-?(Cyclopropylmethyl)?-?2-?(4-?pyridinylamino)?[4,?5'-?bipyrimidin]?-?2'-?yl]?amino]?-?2-?methyl-2-?propanol

inhibit,VPS34,oral,VPS-34 inhibitor 1 (Compound 19, PIK-III analogue),Inhibitor,VPS34 inhibitor 1 (Compound 19, PIK III analogue),lysosomal,degradation,Phosphoinositide 3-kinase,PI3K,selective,VPS34 inhibitor 1 (Compound 19, PIKIII analogue),Autophagy

VPS34 inhibitor 1 (Compound 19)

VPS34 inhibitor 1 (Compound 19, PIK-III analogue), 10 mM in DMSO

VPS34-IN-19

1383716-46-8