Vps
- Product Name
- Vps
- CAS No.
- 1383716-46-8
- Chemical Name
- Vps
- Synonyms
- Compound 19;Vps;VPS34-IN-19;PIK-III analogue;VPS34 inhibitor 1;Compound 19, PIK-III analogue;VPS34 inhibitor 1 (Compound 19);VPS34 inhibitor 1 (PIK-III analogue);VPS34 inhibitor 1 (Compound 19, PIK-III analogue);VPS34 inhibitor 1 (Compound 19, PIK-III analogue), 10 mM in DMSO
- CBNumber
- CB53158772
- Molecular Formula
- C21H25N7O
- Formula Weight
- 391.47
- MOL File
- 1383716-46-8.mol
Vps Property
- Boiling point:
- 676.1±65.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 78 mg/mL (199.25 mM);Ethanol: Insoluble
- pka
- 14.68±0.29(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water: Insoluble
N-Bromosuccinimide Price
- Product number
- C990250
- Product name
- 1-[[4''-(Cyclopropylmethyl)-2-(4-pyridinylamino)[4,5''-bipyrimidin]-2''-yl]amino]-2-methyl-2-propanol
- Packaging
- 5mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CD31004929
- Product name
- VPS34inhibitor1
- Purity
- 95%
- Packaging
- 10mg
- Price
- $309
- Updated
- 2021/12/16
- Product number
- DC10019
- Product name
- VPS34inhibitor1(Compound19,PIK-IIIanalogue)
- Purity
- >98%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CD31004929
- Product name
- VPS34inhibitor1
- Purity
- 95%
- Packaging
- 25mg
- Price
- $527
- Updated
- 2021/12/16
- Product number
- DC10019
- Product name
- VPS34inhibitor1(Compound19,PIK-IIIanalogue)
- Purity
- >98%
- Packaging
- 50mg
- Price
- $900
- Updated
- 2021/12/16
Vps Chemical Properties,Usage,Production
Uses
1-?[[4''-?(Cyclopropylmethyl)?-?2-?(4-?pyridinylamino)?[4,?5''-?bipyrimidin]?-?2''-?yl]?amino]?-?2-?methyl-2-?propanol is a selective PI 3-?kinase VPS34 inhibitor. VPS34 inhibitors can be used to investigate autophagy, a degradation process that recycles cellular components.
Synthesis
1383716-87-7
44838-96-2
1383716-46-8
Synthesis of 1-((4'-(cyclopropylmethyl)-2-(pyridin-4-ylamino)-[4,5'-bipyridin]-2'-yl)amino)-2-methylpropan-2-ol (1 Ot): a new synthesis of 1-((4'-(cyclopropylmethyl)-2-(pyridin-4-ylamino)-[4,5'-bipyridin]-2'-yl)amino)-2-methylpropan-2-ol (1 Ot) was carried out by adding a new synthesizer to the (Z)-1-cyclopropyl-4-(dimethylamino)-3-(2-( pyridin-4-ylamino)pyrimidin-4-yl)but-3-en-2-one (9) (50 mg, 0.155 mmol) was added to a solution of 1-(2-hydroxy-2-methylpropyl)guanidine and potassium carbonate (107 mg, 0.773 mmol) in DMF (1288 μL). The reaction mixture was stirred at 120 °C for 2 hours. Upon completion of the reaction, the crude product was purified by reversed-phase HPLC (gradient: 30-90% organic phase, 15 min), followed by further purification using Biotage? silica gel chromatography (10 g SNAP column, elution gradient: 100% DCM to 12% MeOH/DCM) to afford the target product (23.8 mg, 39% yield).
References
[1] Patent: WO2012/85815, 2012, A1. Location in patent: Page/Page column 65-66
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 1, p. 72 - 76