S49076
- Product Name
- S49076
- CAS No.
- 1265965-22-7
- Chemical Name
- S49076
- Synonyms
- S49076;CS-2684;S4 9076;S4-9076;FGFR,S49076,Fibroblast growth factor receptor,inhibit,c-Met/HGFR,S 49076,Inhibitor,S-49076;3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;(Z)-3-((3-((4-(morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 3-[[2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-
- CBNumber
- CB53159461
- Molecular Formula
- C22H22N4O4S
- Formula Weight
- 438.5
- MOL File
- 1265965-22-7.mol
S49076 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 31 mg/mL (70.70 mM)
- form
- Solid
- color
- Yellow to orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-6191
- Product name
- S49076
- Purity
- 98.62%
- Packaging
- 2mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- CS-6191
- Product name
- S49076
- Purity
- 98.62%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-6191
- Product name
- S49076
- Purity
- 98.62%
- Packaging
- 10mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- CS-6191
- Product name
- S49076
- Purity
- 98.62%
- Packaging
- 50mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- CS-6191
- Product name
- S49076
- Purity
- 98.62%
- Packaging
- 100mg
- Price
- $972
- Updated
- 2021/12/16
S49076 Chemical Properties,Usage,Production
Biological Activity
S49076 is a novel and potent inhibitor of Met (c-Met), AXL/MER and FGFR1/2/3 with IC50 below 20 nM.
in vivo
S49076 effectively inhibits the phosphorylation of MET, AXL and FGFRs in cells, and inhibits their downstream signaling pathways in vitro and in vivo. In cellular models, it inhibits MET and FGFR2-dependent gastric cancer cells, prevents MET-driven migration of lung cancer cells, and inhibits colony formation of liver cancer cells expressing FGFR1/2 and AXL. S49076 inhibits cell viability, motile, three-dimensional colony formation of cancer cells expressing MET, AXL or FGFRs.
in vivo
S49076 has significant antitumor activity in MET- and FGFR-dependent tumor grafts. It is highly distributed in tumors, with a half-life of approximately 7 hours in tumors and less than 2 hours in blood at a dose of 3.125 mg/kg. At doses above 6.25 mg/kg, more than 50% of MET phosphorylation was inhibited for 16 hours. S49076 was also active in a bevacizumab-resistant model, and in combination with bevacizumab, completely inhibited the growth of colon cancer xenografts.
target
| Target | Value |
| Met (Cell-free assay) | 1 nM |
| Mer (Cell-free assay) | 2 nM |
| 7 nM | |
| FGFR3 (Cell-free assay) | 15 nM |
| FGFR2 (Cell-free assay) | 17 nM |
S49076 Preparation Products And Raw materials
Raw materials
Preparation Products
S49076 Suppliers
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- 0510-83588313-802 18800520310;
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- China
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- +86-21-52996696
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- Fax
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- +86 18721201413
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View Lastest Price from S49076 manufacturers
- Product
- S49076 1265965-22-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23