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S49076

Product Name
S49076
CAS No.
1265965-22-7
Chemical Name
S49076
Synonyms
S49076;CS-2684;S4 9076;S4-9076;FGFR,S49076,Fibroblast growth factor receptor,inhibit,c-Met/HGFR,S 49076,Inhibitor,S-49076;3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;(Z)-3-((3-((4-(morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 3-[[2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-
CBNumber
CB53159461
Molecular Formula
C22H22N4O4S
Formula Weight
438.5
MOL File
1265965-22-7.mol
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S49076 Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 31 mg/mL (70.70 mM)
form 
Solid
color 
Yellow to orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
2mg
Price
$72
Updated
2021/12/16
ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
10mg
Price
$156
Updated
2021/12/16
ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
50mg
Price
$540
Updated
2021/12/16
ChemScene
Product number
CS-6191
Product name
S49076
Purity
98.62%
Packaging
100mg
Price
$972
Updated
2021/12/16
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S49076 Chemical Properties,Usage,Production

Biological Activity

S49076 is a novel and potent inhibitor of Met (c-Met), AXL/MER and FGFR1/2/3 with IC50 below 20 nM.

in vivo

S49076 effectively inhibits the phosphorylation of MET, AXL and FGFRs in cells, and inhibits their downstream signaling pathways in vitro and in vivo. In cellular models, it inhibits MET and FGFR2-dependent gastric cancer cells, prevents MET-driven migration of lung cancer cells, and inhibits colony formation of liver cancer cells expressing FGFR1/2 and AXL. S49076 inhibits cell viability, motile, three-dimensional colony formation of cancer cells expressing MET, AXL or FGFRs.

in vivo

S49076 has significant antitumor activity in MET- and FGFR-dependent tumor grafts. It is highly distributed in tumors, with a half-life of approximately 7 hours in tumors and less than 2 hours in blood at a dose of 3.125 mg/kg. At doses above 6.25 mg/kg, more than 50% of MET phosphorylation was inhibited for 16 hours. S49076 was also active in a bevacizumab-resistant model, and in combination with bevacizumab, completely inhibited the growth of colon cancer xenografts.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> Axl
(Cell-free assay)
TargetValue
Met
(Cell-free assay)		 1 nM
Mer
(Cell-free assay)		 2 nM
7 nM
FGFR3
(Cell-free assay)		 15 nM
FGFR2
(Cell-free assay)		 17 nM

S49076 Preparation Products And Raw materials

Raw materials

Preparation Products

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S49076 Suppliers

China 45 India 1 United States 6 Global 52
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
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View Lastest Price from S49076 manufacturers

Career Henan Chemical Co
Product
S49076 1265965-22-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

1265965-22-7, S49076Related Search:


  • S49076
  • CS-2684
  • S4 9076;S4-9076
  • 2,4-Thiazolidinedione, 3-[[2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-
  • FGFR,S49076,Fibroblast growth factor receptor,inhibit,c-Met/HGFR,S 49076,Inhibitor,S-49076
  • (Z)-3-((3-((4-(morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione
  • 3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione
  • 1265965-22-7