6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
- Product Name
- 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
- CAS No.
- 724422-42-8
- Chemical Name
- 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
- Synonyms
- 6-bromo-2-methyl-3,4-dihydroisoquinolin-1-one;6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one;1(2H)-ISOQUINOLINONE, 6-BROMO-3,4-DIHYDRO-2-METHYL-;6-bromo-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-one
- CBNumber
- CB53161882
- Molecular Formula
- C10H10BrNO
- Formula Weight
- 240.1
- MOL File
- 724422-42-8.mol
6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P000053041
- Product name
- 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
- Purity
- 97%
- Packaging
- 100mg
- Price
- $20
- Updated
- 2021/12/16
- Product number
- P000053041
- Product name
- 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $37
- Updated
- 2021/12/16
- Product number
- P000053041
- Product name
- 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $92
- Updated
- 2021/12/16
- Product number
- 9992DS
- Product name
- 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
- Packaging
- 100mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 9992DS
- Product name
- 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
- Packaging
- 250mg
- Price
- $126
- Updated
- 2021/12/16
6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Usage,Production
Synthesis
147497-32-3
74-88-4
724422-42-8
General procedure for the synthesis of 6-bromo-2-methyl-3,4-dihydro-2H-isoquinolin-1(2H)-one from 6-bromo-3,4-dihydro-2H-isoquinolin-1-one and iodomethane: 6-bromo-3,4-dihydro-2H-isoquinolin-1-one (500 mg, 2.2 mmol) was dissolved in DMF (3 mL) and the solution was cooled down to 0 °C. Under argon protection, 60% NaH (121 mg, 3.0 mmol) was added and the reaction mixture was stirred for 20 min. Subsequently, methyl iodide (0.275 mL, 4.4 mmol) was added and stirring was continued at 0 °C for 1 hour. Upon completion of the reaction, ice water was added to the mixture and the precipitate was collected by filtration. The resulting solid was dried in a vacuum oven at 50 °C for 12 h to afford the target product 6-bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one in 73% yield. Spectral analysis of the product showed m/z 240/242 [M + H]+ with a retention time (rt) of 0.89 min (LC-MS method V012_S01).
References
[1] Patent: WO2014/140075, 2014, A1. Location in patent: Page/Page column 209-210
[2] Patent: US2014/275025, 2014, A1. Location in patent: Paragraph 0537; 0538
[3] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 0852; 0855; 0856
[4] Patent: US2018/51013, 2018, A1. Location in patent: Paragraph 0597; 0599
6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one manufacturers
- Product
- 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one 724422-42-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19