ChemicalBook > CAS DataBase List > 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione

2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione

Product Name
2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
CAS No.
79756-69-7
Chemical Name
2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
Synonyms
TPI-1;TPI1;TPI 1;TPI-1, 10 mM in DMSO;TPI-1,Inhibitor,inhibit,Phosphatase;2-(2,5-Dichlorophenyl)-1,4-benzoquinone;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;Recombinant Human TIM/TPI1 Protein, His Tag;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
CBNumber
CB53169525
Molecular Formula
C12H6Cl2O2
Formula Weight
253.08
MOL File
79756-69-7.mol
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2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Property

storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
color 
White to yellow
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Safety

HS Code 
2914698090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22480
Product name
TPI-1
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
22480
Product name
TPI-1
Purity
≥95%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
22480
Product name
TPI-1
Purity
≥95%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
22480
Product name
TPI-1
Purity
≥95%
Packaging
25mg
Price
$573
Updated
2024/03/01
Usbiological
Product number
359427
Product name
Tpi1
Packaging
48Tests
Price
$588
Updated
2021/12/16
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2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Chemical Properties,Usage,Production

Biological Activity

TPI-1 (Tyrosine Phosphatase Inhibitor 1) is a potent SHP-1 inhibitor with IC50 of 40 nM for recombinant SHP-1. It has anticancer activity.

in vitro

SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. It selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ + cells and induces IFNγ < sup> + cells in human peripheral blood.

in vivo

TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. It thus also increases pLck-pY394 and IFNγ + cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated sc agent.

target

TargetValue
SHP-1
(Cell-free assay)		 40 nM

2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Suppliers

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79756-69-7, 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dioneRelated Search:


  • TPI-1
  • 2-(2,5-Dichlorophenyl)-1,4-benzoquinone
  • TPI1;TPI 1
  • 2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-
  • Recombinant Human TIM/TPI1 Protein, His Tag
  • 2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione
  • TPI-1,Inhibitor,inhibit,Phosphatase
  • 2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione
  • 2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
  • TPI-1, 10 mM in DMSO
  • 79756-69-7