2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
- Product Name
- 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
- CAS No.
- 79756-69-7
- Chemical Name
- 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
- Synonyms
- TPI-1;TPI1;TPI 1;TPI-1,Inhibitor,inhibit,Phosphatase;2-(2,5-Dichlorophenyl)-1,4-benzoquinone;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;Recombinant Human TIM/TPI1 Protein, His Tag;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
- CBNumber
- CB53169525
- Molecular Formula
- C12H6Cl2O2
- Formula Weight
- 253.08
- MOL File
- 79756-69-7.mol
2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Property
- storage temp.
- 2-8°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
Safety
- HS Code
- 2914698090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 22480
- Product name
- TPI-1
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 22480
- Product name
- TPI-1
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 22480
- Product name
- TPI-1
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 22480
- Product name
- TPI-1
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $573
- Updated
- 2024/03/01
- Product number
- 359427
- Product name
- Tpi1
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Chemical Properties,Usage,Production
Biological Activity
TPI-1 (Tyrosine Phosphatase Inhibitor 1) is a potent SHP-1 inhibitor with IC50 of 40 nM for recombinant SHP-1. It has anticancer activity.
in vitro
SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. It selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ + cells and induces IFNγ < sup> + cells in human peripheral blood.
in vivo
TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. It thus also increases pLck-pY394 and IFNγ + cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated sc agent.
target
| Target | Value |
| SHP-1 (Cell-free assay) | 40 nM |