TRC051384

Product Name: TRC051384
CAS No.: 867164-40-7
Chemical Name: TRC051384
Synonyms: TRC051384;TRC 051384; TRC-051384;HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit;1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea;N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea;Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-
CBNumber: CB53171704
Molecular Formula: C25H31N5O4
Formula Weight: 465.54
MOL File: 867164-40-7.mol

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TRC051384 Property

Boiling point:: 685.7±55.0 °C(Predicted)
Density: 1.260±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥109 mg/mL in DMSO
form: solid
pka: 13.47±0.46(Predicted)
color: Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4734
Product name: TRC051384
Purity: ≥98%(HPLC)
Packaging: 10
Price: $273
Updated: 2021/12/16

Usbiological

Product number: 256966
Product name: TRC 051384
Packaging: 10mg
Price: $545
Updated: 2021/12/16

TRC

Product number: T895540
Product name: TRC051384
Packaging: 10mg
Price: $255
Updated: 2021/12/16

ChemScene

Product number: CS-6513
Product name: TRC051384
Purity: 98.19%
Packaging: 200mg
Price: $2400
Updated: 2021/12/16

ChemScene

Product number: CS-6513
Product name: TRC051384
Purity: 98.19%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

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TRC051384 Chemical Properties,Usage,Production

Uses

N-[2-(4-Morpholinyl)ethyl]-N''-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea is a key reactant in the synthesis of TRC051384, which is a small molecule HSP70 inducer.

Biological Activity

trc 051384, belonging to substituted 2-propen-1-one class, is a potent inducer of heat shock protein 70 (hsp70) [1]. induction of hsp70 is a natural response of stressed cells that protects neuronal cells from a variety of insults including acute ischemia. therefore, induction of hsp70 provides a potential target for the treatment of stroke [1].

in vitro

induction of hsp70 by trc 051384 (6.25, and 12.5 μm) involved heat shock factor-1 (hsf1) activation in hela cells and led to increasing chaperone and anti-inflammatory activity [1]. moreover, trc 051384 (10-50 μm) dose-dependently induced hspa1b overexpression in endothelial cells as well as leucocyte origin [2].

in vivo

trc 051384 (9 mg/kg, intra-peritoneal administration) treatment significantly decreased stroke-associated neuronal injury, disability, and increased survival in a rat model of transient ischemic stroke [1]. in addition, trc 051384 (9 mg/kg, intra-peritoneal administration) delayed thrombus formation without increasing bleeding risk in wt mice [2].

target

hsp70

References

1. mohanan a, deshpande s, jamadarkhana pg, kumar p, gupta rc, chauthaiwale v, et al. delayed intervention in experimental stroke with trc 051384--a small molecule hsp70 inducer. neuropharmacology. 2011;60(6):991-9. 2. allende m, molina e, guruceaga e, tamayo i, gonzalez-porras jr, gonzalez-lopez tj, et al. hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk. cardiovasc res. 2016;110(3):309-18.

TRC051384 Preparation Products And Raw materials

Raw materials

Preparation Products

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TRC051384 Suppliers

China 49 India 1 United Kingdom 1 United States 8 USA 1 Global 60

Guangzhou Isun Pharmaceutical Co., Ltd

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Tianjin Kailiqi Biotechnology Co., Ltd.

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Beijing Solarbio Science & Tecnology Co., Ltd.

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Angel Pharmatech, Ltd.

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Guangzhou Tomums Life Science Co., Ltd.

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InvivoChem

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Career Henan Chemica Co

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DC Chemicals

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Changzhou Chenhong Biotechnology Co., Ltd.

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Absin Bioscience Inc.

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867164-40-7, TRC051384Related Search:

TRC051384 Troparil dichloropane

TRC051384

TRC 051384; TRC-051384

N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea

Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-

1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea

HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit

867164-40-7

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