ChemicalBook > CAS DataBase List > 3-Mercapto-1,2-propanediol

3-Mercapto-1,2-propanediol

Product Name
3-Mercapto-1,2-propanediol
CAS No.
96-27-5
Chemical Name
3-Mercapto-1,2-propanediol
Synonyms
MONOTHIOGLYCEROL;1-THIOGLYCEROL;THIOGLYCEROL;1-Mercaptoglycerol;3-Mercaptopropane-1,2-diol;ALPHA-THIOGLYCEROL;THIOGLYCERIN;A-MONOTHIOGLYCEROL;1-Mercapto-2,3-propanediol;Thiovanol
CBNumber
CB5325331
Molecular Formula
C3H8O2S
Formula Weight
108.16
MOL File
96-27-5.mol
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3-Mercapto-1,2-propanediol Property

Melting point:
<25 °C
Boiling point:
118 °C5 mm Hg(lit.)
Density 
1.25 g/mL at 25 °C(lit.)
vapor pressure 
<1 hPa (20 °C)
refractive index 
n20/D 1.527(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
absolute ethanol: 1 mL/mL
form 
liquid
pka
pK1:9.43 (25°C,μ=0.5)
color 
Clear colorless to yellow
Odor
Stench odour
PH
3.5-7.0
Water Solubility 
slightly soluble
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,9335
BRN 
1732046
Stability:
Air Sensitive, Hygroscopic
InChIKey
PJUIMOJAAPLTRJ-UHFFFAOYSA-N
LogP
-0.84 at 20℃
CAS DataBase Reference
96-27-5(CAS DataBase Reference)
NIST Chemistry Reference
Monothioglycerol(96-27-5)
EPA Substance Registry System
1,2-Propanediol, 3-mercapto- (96-27-5)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
21/22-36/37/38
Safety Statements 
26-36-23
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
RTECS 
TY8140000
F 
3-9-10-13-23
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29309070
Hazardous Substances Data
96-27-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.41705
Product name
3-Mercapto-1,2-propanediol
Purity
for synthesis
Packaging
50mL
Price
$121
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41705
Product name
3-Mercapto-1,2-propanediol
Purity
for synthesis
Packaging
250ML
Price
$326
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41705
Product name
3-Mercapto-1,2-propanediol
Purity
for synthesis
Packaging
1L
Price
$588
Updated
2024/03/01
TCI Chemical
Product number
S0374
Product name
alpha-Thioglycerol [Matrix for FABMS and liquid SIMS]
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$24
Updated
2024/03/01
TCI Chemical
Product number
S0374
Product name
alpha-Thioglycerol [Matrix for FABMS and liquid SIMS]
Purity
>98.0%(GC)(T)
Packaging
10g
Price
$95
Updated
2024/03/01
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3-Mercapto-1,2-propanediol Chemical Properties,Usage,Production

Description

1-Thioglycerol is a reagent used in fluorescence, spectroscopy, and microbiology techniques. Varying the concentration of 1-thioglycerol in the preparation of CdSe/CdS core-shell ultrasmall quantum dots (CS-USQDs) allows a precise way to control the size of the shell, with shell size increasing with increased concentration. It is used as a capping agent in the synthesis of nanocrystals analyzed via Raman and UV/Vis spectroscopy. Biologically, 1-thioglycerol stimulates porphyrin synthesis and increases glutamyl-tRNA reductase activity in E. coli grown in an aerobic environment. It was previously a component in hair permanents used to produce waves or curls.

Chemical Properties

clear colorless to yellowish viscous solution

Chemical Properties

Monothioglycerol occurs as a colorless or pale-yellow colored, viscous, hygroscopic liquid with a slight odor of sulfide.

Uses

It generally used as a size-regulating capping agent for nanocrystals. 1-Thioglycerol is also used in bacteriology experiments to induce the synthesis of porphyrin compounds in aerobically growing Escherichia coli. Also used to study the pH-sensitive photoluminescence of aqueous thiol-capped CdTe nanocrystals. 1-Thioglycerol is used to develop and test thiol functionalized copolymers. 1-Thioglycerol is used as a post-modification agent in the generation of non-standard peptide foldamers.Potential substitute for 2-mercaptoethanol, probe for the study of lymphocyte activation.

Uses

3-Mercapto-1,2-propanediol can be used as antioxidant preservative; reagent in analytical chemistry, cell culture research. Matrix substrate in fast atom bombardment mass spectrometry.

Uses

3-Mercapto-1,2-propanediol has been used in a study to assess the manipulation of aqueous growth of CdTe nanocrystals. It has also been used in a study that investigated the effect of surface attachment on ligand binding

Production Methods

Monothioglycerol is prepared by heating an ethanolic solution of 3- chloro-1,2-propanediol with potassium bisulfide.

Definition

ChEBI: A thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group.

General Description

1-Thioglycerol stimulates the synthesis of porphyrin in aerobically growing Escherichia coli. It is an inhibitor of glycerol kinase activity in vitro and in situ.

Pharmaceutical Applications

Monothioglycerol is used as an antioxidant in pharmaceutical formulations, mainly in parenteral preparations.Monothioglycerol is reported to have some antimicrobial activity.It is also widely used in cosmetic formulations such as depilating agents.
Therapeutically, monothioglycerol has been used in a 0.02% w/w aqueous solution to stimulate wound healing, and as a 0.1% w/w jelly in atrophic rhinitis.

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental reproductive effects. Mutation data reported. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits hghly toxic fumes of SOx.

Safety

Monothioglycerol is generally regarded as a relatively nontoxic and nonirritant material at the concentrations used as a pharmaceutical excipient. It is used in topical and injectable preparations. Undiluted monothioglycerol is considered a poison by the IP and IV routes; it has also been reported to be mutagenic.
LD50 (cat, IV): 0.22 g/kg
LD50 (mouse, IP): 0.34 g/kg
LD50 (rabbit, IV): 0.25 g/kg
LD50 (rat, IP): 0.39 g/kg

storage

Monothioglycerol is unstable in alkaline solutions. Monothioglycerol should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Monothioglycerol can react with oxidizing materials.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM, IV and other injections). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

3-Mercapto-1,2-propanediol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Mercapto-1,2-propanediol Suppliers

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View Lastest Price from 3-Mercapto-1,2-propanediol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
3-Mercapto-1,2-propanediol 96-27-5
Price
US $75.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-30
Shaanxi Dideu New Materials Co. Ltd
Product
3-Mercapto-1,2-propanediol 96-27-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2024-11-06
Shaanxi Dideu New Materials Co. Ltd
Product
monothioglycerol 96-27-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2024-11-12

96-27-5, 3-Mercapto-1,2-propanediolRelated Search:

6-Mercaptopurine 3-Mercaptopropionic acid Calcium thioglycolate Thioacetamide (R)-(-)-1,2-Propanediol Sodium thioglycolate Propylene glycol Thiosalicylic acid 2-Mercaptobenzothiazole Mercaptoacetic acid Ammonium thiosulfate Thioacetic acid Sodium thiosulfate 2-Thiobarbituric acid 2-Ethylhexyl mercaptoacetate 2-Mercaptoethanol Malathion Octyl thioglucoside

  • ALPHA-THIOGLYCEROL
  • ALPHA-MONOTHIOGLYCEROL
  • A-MONOTHIOGLYCEROL
  • 3-MERCAPTO-1,2-PROPANDIOL
  • 3-MERCAPTO-1,2-PROPANEDIOL
  • 1,2-Propanediol, 3-mercapto-
  • 1-Mercapto-2,3-propanediol
  • 1-Mercaptoglycerol
  • 1-Monothioglycerol
  • 1-Thio-2,3-propanediol
  • 1-Thiogylcerol
  • 2,3-Dihydroxypropanethiol
  • 3-mercapto-propane-1,2-diol
  • 3-Mercaptopropane-1,2-diol
  • 3-Sulfanyl-1,2-propanediol
  • alpha-Thiolglycerol
  • Glycerol, 1-thio-
  • Glycerol-1-thiol
  • Monothioglycerin
  • Thioglycerine
  • Thiovanol
  • USAF B-40
  • USAF cb-37
  • MERCAPTOGLYCEROL
  • 1-THIOGLYCEROL
  • MONOTHIOGLYCEROL
  • 1-Thioglycerol,α-Monothioglycerol, α-Thioglycerol, 3-Mercapto-1,2-propanediol
  • 2,3-Dihydroxypropane-1-thiol, 3-Sulfanylpropane-1,2-diol, Mercapto glycerol, Thioglycerol
  • 3-Thiopropane-1,2-diol, NF grade
  • alpha-Thioglycerol&nbsp
  • 3-Mercapto-1,2-propanediol, 90 wt% aqueous solution 100ML
  • 3-Mercapto-1,2-propanediol, 90 wt% aqueous solution 25ML
  • 3-Thiopropane-1,2-diol 97%
  • Thioglycerol, 3-Mercaptopropane-1,2-diol
  • 2,3-Dihydroxypropane-1-thiol, 3-Sulphanylpropane-1,2-diol, Mercapto glycerol, Thioglycerol
  • 1-Thioglycerol 〔3-Mercapto-1,2-Propanediol〕
  • α-Thioglycerol [Matrix for FABMS and liquid SIMS]
  • 3-Mercapto-1,2-propanediol for synthesis
  • THIOGLYCERIN
  • THIOGLYCEROL
  • MONOTHIOGLYCEROL, CELL CULTURE TESTED
  • 1-THIOGLYCEROL, MATRIX SUBSTANCE FOR FAB -MS
  • 1-THIOGLYCEROL 90 % IN WATER
  • 1-THIOGLYCEROL, DIST.
  • A-MONOTHIOGLYCEROL SIGMAULTRA
  • 3-MERCAPTO-1,2-PROPANEDIOL 90 WT% AQUEOUS SOLUTION
  • 3-MERCAPTO-1,2-PROPANEDIOL, MIN. 98%, REAGENT GRADE
  • 1-Thioglycerol,>89%
  • 3-Mercapto-1,2-propanediol, tech., 90%
  • 1-THIOGLYCEROL GR 90%
  • 3-MERCAPTO-1,2-PROPANEDIOL(1-THIOGLYCEROL))
  • 3-THIOGLYCEROL
  • 3-MERCAPTO-1,2-PROPANEDIOL 90+%
  • alpha-Thioglycerol [Matrix for FABMS and liquid SIMS]
  • 3-MERCAPTO-1,2-PROPANEDIOL pure
  • α-Monothioglycerol, α-Thioglycerol, 3-Mercapto-1,2-propanediol
  • 3-Sulfanylpropane-1,2-diol
  • Mercapto-1,2-propanediol