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Nifekalant

Product Name: Nifekalant
CAS No.: 130636-43-0
Chemical Name: Nifekalant
Synonyms: NIFEKALANT;NIFEKALANT HCL;Nifekalant USP/EP/BP;OEBPANQZQGQPHF-UHFFFAOYSA-N;1-(3,4-dichlorophenyl)-3-hexylurea;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylami...;6-((2-((2-hydroxyethyl)(3-(p-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethyl-uracil;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethyl-pyrimidine-2,4-dione;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethyl-pyrimidine-2,4-quinone;NIFEKALANT [6-((2-((2-HYDROXYETHYL)(3-(P-NITROPHENYL)PROPYL)AMINO)ETHYL)AMINO)-1,3-DIMETHYL-URACIL]
CBNumber: CB5325412
Molecular Formula: C19H27N5O5
Formula Weight: 405.45
MOL File: 130636-43-0.mol

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Nifekalant Property

Melting point:: 117.5-118.5°; mp 125-126° (Katakami, 1992)
Boiling point:: 597.9±60.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
pka: 14.74±0.10(Predicted)
CAS DataBase Reference: 130636-43-0(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0015401
Product name: NIFEKALANT
Purity: 95.00%
Packaging: 5MG
Price: $496.39
Updated: 2021/12/16

AHH

Product number: MT-56993
Product name: Nifekalant
Purity: 98%
Packaging: 0.25g
Price: $560
Updated: 2021/12/16

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Nifekalant Chemical Properties,Usage,Production

Uses

Nifekalant (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 μM. Nifekalant can be used for refractory ventricular tachyarrhythmias research[1][2].

Definition

ChEBI: Nifekalant is an amine.

in vivo

In rats (a species deficient in functional cardiac IK), before coronary ligation, 3 mg/kg and 10 mg/kg MS-551 decreased the heart rate by 6% and 12%, and increased mean arterial pressure (MAP) by 14% and 33%, respectively. MS-551 prolongs the QT interval and reduced the incidence of sustained ventricular fibrillation (VF) after reperfusion^[3].

References

[1] Lü-Pei Du, et al. The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4771-7. DOI:10.1016/j.bmcl.2004.06.070
[2] Ioannis N Pantazopoulos, et al. Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias. World J Cardiol. 2011 Jun 26;3(6):169-76. DOI:10.4330/wjc.v3.i6.169
[3] J Chen, et al. IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats. Br J Pharmacol. 1996 Nov;119(5):937-42. DOI:10.1111/j.1476-5381.1996.tb15762.x

Nifekalant Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nifekalant manufacturers

Career Henan Chemical Co

Product: Nifekalant 130636-43-0
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

130636-43-0, NifekalantRelated Search:

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NIFEKALANT

NIFEKALANT HCL

6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethyl-pyrimidine-2,4-dione

6-((2-((2-hydroxyethyl)(3-(p-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethyl-uracil

1,3-dimethyl-6-[2-(n-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino]-2,4(1h,3h)-pyrimidinedione hydrochloride

NIFEKALANT [6-((2-((2-HYDROXYETHYL)(3-(P-NITROPHENYL)PROPYL)AMINO)ETHYL)AMINO)-1,3-DIMETHYL-URACIL]

6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethyl-pyrimidine-2,4-quinone

OEBPANQZQGQPHF-UHFFFAOYSA-N

1-(3,4-dichlorophenyl)-3-hexylurea

6-((2-((2-Hydroxyethyl)(3-(4-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

2,4(1H,3H)-Pyrimidinedione, 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-

Nifekalant USP/EP/BP

6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylami...

6-((2-((2-hydroxyethyl)(3-(4-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride

130636-43-0

C19H28ClN5O5

C19H27N5O5

API