3-BROMO-2-HYDROXY-5-NITROBENZALDEHYDE
- Product Name
- 3-BROMO-2-HYDROXY-5-NITROBENZALDEHYDE
- CAS No.
- 16789-84-7
- Chemical Name
- 3-BROMO-2-HYDROXY-5-NITROBENZALDEHYDE
- Synonyms
- AKOS BC-1820;ASISCHEM R25237;3-BROMO-5-NITROSALICYLALDEHYDE;3-Bromo-5-nitrosalicylaldehyde >3-BROMO-2-HYDROXY-5-NITROBENZALDEHYDE;2-Hydroxy-3-bromo-5-nitrobenzaldehyde;Benzaldehyde, 3-bromo-2-hydroxy-5-nitro-;3-BROMO-2-HYDROXY-5-NITROBENZENECARBALDEHYDE
- CBNumber
- CB5333037
- Molecular Formula
- C7H4BrNO4
- Formula Weight
- 246.01
- MOL File
- 16789-84-7.mol
3-BROMO-2-HYDROXY-5-NITROBENZALDEHYDE Property
- Melting point:
- 146-149 °C
- Boiling point:
- 299.6±40.0 °C(Predicted)
- Density
- 1.928±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 3.38±0.44(Predicted)
- color
- Light orange to Yellow to Green
- Sensitive
- Air Sensitive
- BRN
- 1213613
- InChI
- InChI=1S/C7H4BrNO4/c8-6-2-5(9(12)13)1-4(3-10)7(6)11/h1-3,11H
- InChIKey
- BESBCGANGAEHPM-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC([N+]([O-])=O)=CC(Br)=C1O
- CAS DataBase Reference
- 16789-84-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 652784
- Product name
- 3-Bromo-5-nitrosalicylaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $102
- Updated
- 2023/06/20
- Product number
- 652784
- Product name
- 3-Bromo-5-nitrosalicylaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $303
- Updated
- 2023/06/20
- Product number
- B3198
- Product name
- 3-Bromo-5-nitrosalicylaldehyde
- Purity
- >95.0%(GC)(T)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- B3198
- Product name
- 3-Bromo-5-nitrosalicylaldehyde
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $192
- Updated
- 2025/07/31
- Product number
- B677933
- Product name
- 3-Bromo-2-hydroxy-5-nitrobenzaldehyde
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
3-BROMO-2-HYDROXY-5-NITROBENZALDEHYDE Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 5867, 2007 DOI: 10.1021/jo070477u
Synthesis
97-51-8
16789-84-7
General procedure for the synthesis of 3-bromo-2-hydroxy-5-nitrobenzaldehyde from 5-nitrosalicylaldehyde: 2-hydroxy-5-nitrobenzaldehyde (2.0 g, 12 mmol) and dichloromethane (30 mL) were added to a 100 mL two-necked flask, followed by the addition of bromine (2.24 g, 14 mmol) dropwise. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium thiosulfate (100 mL) and the mixture was transferred to a separatory funnel for layering. The aqueous phase was extracted with ethyl acetate (100 mL × 2). The organic phases were combined, washed with saturated brine (80 mL × 2), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether, v/v = 1/20) to afford 3-bromo-2-hydroxy-5-nitrobenzaldehyde as a yellow solid (2.89 g, 98% yield). Mass spectrum (ES-API, cation mode) m/z: 246.9 [M + 2]+.
References
[1] Organic Letters, 2011, vol. 13, # 1, p. 26 - 29
[2] Tetrahedron Letters, 2005, vol. 46, # 51, p. 8959 - 8963
[3] Patent: WO2017/36404, 2017, A1. Location in patent: Page/Page column 115
[4] Journal of Organic Chemistry, 2007, vol. 72, # 15, p. 5867 - 5869
[5] Patent: CN108623615, 2018, A. Location in patent: Paragraph 0332; 0547; 0548; 0549
3-BROMO-2-HYDROXY-5-NITROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-2-HYDROXY-5-NITROBENZALDEHYDE manufacturers
- Product
- 3-BROMO-2-HYDROXY-5-NITROBENZALDEHYDE 16789-84-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04