Niraparib tosylate

FDA Approved

Product Name: Niraparib tosylate
CAS No.: 1613220-15-7
Chemical Name: Niraparib tosylate
Synonyms: Niraparib TOS H2O;MK4827 tosylate Hydrate;MK 4827 tosylate Hydrate;MK-4827 tosylate Hydrate;Niraparib monohydrate API;Niraparib tosylate hydrate;Niraparib TsOH salt hydrate;Nilapani toluene monohydrate;Niraparib tosylate monohyrate;Niraparib tosylate hydrate (MK4827)
CBNumber: CB53336280
Molecular Formula: C26H28N4O4S
Formula Weight: 492.59
MOL File: 1613220-15-7.mol

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Niraparib tosylate Property

solubility: DMSO: ~64 mg/mL (~199.8 mM)；Ethanol: ~64 mg/mL
form: Solid
color: White to off-white
InChIKey: LCPFHXWLJMNKNC-XOIICWPPNA-N
SMILES: S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N |&1:23,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H340May cause genetic defects

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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Niraparib tosylate Chemical Properties,Usage,Production

FDA Approved

Yes

Uses

Niraparib tosylate hydrate is a sulfonic acid organic compound that can be used as a pharmaceutical intermediate.

Mechanism of action

Niraparib tosylate is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells.

Synthesis

(S)-3-(4-aminophenyl)piperidine was obtained by chiral resolution, then condensed with methyl 3-formyl-2-nitrobenzoate to construct a pyrazole ring in the presence of sodium azide. Niraparib was subsequently synthesized under ammonia and acidic conditions.

Niraparib tosylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Niraparib tosylate Suppliers

China 180 India 3 United States 4 Global 187

Kaixin Chemical (Hong Kong) Limited

Tel: 010-88886666-01 13112345678
Fax: CDXH21@126.com
Email: loyson@tcypharm.com
Country: China
ProdList: 597
Advantage: 55

Anhui nuoquan pharmaceutical co. LTD

Tel: 15705561919
Fax: 0556-5032869
Email: chunli.yi@nuozhanchem.com
Country: China
ProdList: 101
Advantage: 55

Nanjing Becas pharmatech Ltd.

Tel: 13912903754
Email: info@becaspharma.com
Country: China
ProdList: 2997
Advantage: 58

NanJing Vtrying Pharmatech Co.,Ltd

Tel: 17314186806
Email: Vtrying_sale@163.com
Country: China
ProdList: 167
Advantage: 58

Sichuan Qingmu Pharmaceutical Co., Ltd.

Tel: 028-87827187 18681376319
Email: sales@eastonpharma.cn
Country: China
ProdList: 65
Advantage: 60

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 483
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 8000
Advantage: 58

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View Lastest Price from Niraparib tosylate manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Niraparib Tosylate Monohydrate 1613220-15-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-04-12

Shaanxi Dideu New Materials Co. Ltd

Product: Niraparib tosylate 1613220-15-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-05

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Niraparib Tosylate Monohydrate 1613220-15-7
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-24

1613220-15-7, Niraparib tosylateRelated Search:

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MK-4827, Niraparib TsOH salt hydrate

Niraparib tosylate monohyrate

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate hydrate

Niraparib TsOH salt hydrate

Nilapani toluene monohydrate

Niraparib TOS H2O

Niraparib tosylate hydrate

Niraparib Tosylate Monohydrate (API)

Niraparib tosylate hydrate (MK4827)

Niraparib tosylate monohydrateQ: What is Niraparib tosylate monohydrate Q: What is the CAS Number of Niraparib tosylate monohydrate

Toluenesulfonic nilapani monohydrate

2-[4-(3S)-3-Piperidinylphenyl]-2H-indazole-7-carboxamide 4-methylbenzenesulfonate hydrate (1:1:1)

2-[4-(3S)-3-Piperidinylphenyl]-2H-indazole-7-carboxamide 4-methylbenzenesulfonate hydrate

Niraparib monohydrate API

2-[4-((3S)-3-piperidinyl)phenyl]-2H-indazole-7-carboxamide p-toluenesulfonic acid salt hydrate

MK 4827 tosylate Hydrate

MK4827 tosylate Hydrate

MK-4827 tosylate Hydrate

Toluenesulfonic acid nilaparib monohydrate

Niraparib tosylate monohyrate, 10 mM in DMSO

Nilapani toluenesulfonate monohydrate

1613220-15-7

API

1613220-15-7