Ac-Gly-BoroPro

Product Name: Ac-Gly-BoroPro
CAS No.: 886992-99-0
Chemical Name: Ac-Gly-BoroPro
Synonyms: Ac-Gly-BoroPro;Ac-Gly-BoroPro?, >98%;AcGlyBoroPro,Ac Gly BoroPro;Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-
CBNumber: CB53339599
Molecular Formula: C8H15BN2O4
Formula Weight: 214.03
MOL File: 886992-99-0.mol

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Ac-Gly-BoroPro Property

Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: DMSO : ≥ 50 mg/mL (233.61 mM)
form: Solid
pka: 9.72±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Ac-Gly-BoroPro Chemical Properties,Usage,Production

Biological Activity

Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki value of 23 nM.

in vitro

FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K _i =23±3 nM).

target

Ki: 23 nM (FAP)

Ac-Gly-BoroPro Preparation Products And Raw materials

Raw materials

Preparation Products

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Ac-Gly-BoroPro Suppliers

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886992-99-0, Ac-Gly-BoroProRelated Search:

Ac-Gly-BoroPro

Ac-Gly-BoroPro?, >98%

Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-

AcGlyBoroPro,Ac Gly BoroPro

886992-99-0