Ac-Gly-BoroPro
- Product Name
- Ac-Gly-BoroPro
- CAS No.
- 886992-99-0
- Chemical Name
- Ac-Gly-BoroPro
- Synonyms
- Ac-Gly-BoroPro;Ac-Gly-BoroPro?, >98%;AcGlyBoroPro,Ac Gly BoroPro;Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-
- CBNumber
- CB53339599
- Molecular Formula
- C8H15BN2O4
- Formula Weight
- 214.03
- MOL File
- 886992-99-0.mol
Ac-Gly-BoroPro Property
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- DMSO : ≥ 50 mg/mL (233.61 mM)
- form
- Solid
- pka
- 9.72±0.20(Predicted)
- color
- White to off-white
Ac-Gly-BoroPro Chemical Properties,Usage,Production
Uses
Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.
Biological Activity
Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki value of 23 nM.
in vitro
FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K i =23±3 nM).
target
Ki: 23 nM (FAP)
References
[1] Edosada CY, et al. Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity. J Biol Chem. 2006 Mar 17;281(11):7437-44. DOI:10.1074/jbc.M511112200
Ac-Gly-BoroPro Preparation Products And Raw materials
Raw materials
Preparation Products
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