ChemicalBook > CAS DataBase List > BOC-4-AMINOBENZYLALCOHOL

BOC-4-AMINOBENZYLALCOHOL

Product Name: BOC-4-AMINOBENZYLALCOHOL
CAS No.: 144072-29-7
Chemical Name: BOC-4-AMINOBENZYLALCOHOL
Synonyms: BOC-4-AMINOBENZYLALCOHOL;4-(Boc-aMino)benzyl alcohol;tert-Butyl (4-(hydroxymethyl);TERT-BUTYL 4-(HYDROXYMETHYL)PHENYLCARBAMATE;4-benzyl alcohol;tert-butyl N-[4-(hydroxyMethyl)phenyl]carbaMate;CarbaMic acid N-[4-(hydroxyMethyl)phenyl]-1,1-diMethyl ester;Carbamic acid, N-[4-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester
CBNumber: CB5334423
Molecular Formula: C12H17NO3
Formula Weight: 223.27
MOL File: 144072-29-7.mol

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BOC-4-AMINOBENZYLALCOHOL Property

Melting point:: 74-76 °C
Boiling point:: 310.0±25.0 °C(Predicted)
Density: 1.161±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.66±0.70(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: B603063
Product name: 4-(Boc-amino)benzylAlcohol
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR962629
Product name: 4-(Boc-amino)benzylalcohol
Purity: 97%
Packaging: 1g
Price: $218
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0008019
Product name: BOC-4-AMINOBENZYLALCOHOL
Purity: 95.00%
Packaging: 5G
Price: $724.5
Updated: 2021/12/16

Apolloscientific

Product number: OR962629
Product name: 4-(Boc-amino)benzylalcohol
Purity: 97%
Packaging: 5g
Price: $731
Updated: 2021/12/16

AK Scientific

Product number: 7089AA
Product name: tert-Butyl(4-(hydroxymethyl)phenyl)carbamate
Packaging: 1g
Price: $105
Updated: 2021/12/16

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BOC-4-AMINOBENZYLALCOHOL Chemical Properties,Usage,Production

Synthesis

24424-99-5

623-04-1

144072-29-7

General procedure: p-Aminobenzyl alcohol (1 g, 8.12 mmol, 1 eq.) was dissolved in 80 mL of anhydrous tetrahydrofuran (THF) under nitrogen protection. To this solution was sequentially added N,N-diisopropylethylamine (DIEA, 1.4 mL, 8.12 mmol, 1 eq.) and di-tert-butyl dicarbonate (Boc2O, 1.9 mL, 8.12 mmol, 1 eq.). The reaction mixture was heated to reflux and stirred overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure in a rotary evaporator to remove the solvent. The residue was dissolved in ethyl acetate (EtOAc) and the organic layer was washed with 0.1 N hydrochloric acid solution to remove unreacted amine and DIEA.The organic layer was dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated again under reduced pressure. The crude product was purified by silica gel column chromatography with petroleum ether-ethyl acetate (1:1, v/v) as eluent to afford BOC-4-aminobenzyl alcohol (1.85 g, quantitative yield). The structure of the product was confirmed by 1H NMR and 13C NMR: 1H NMR (CDCl3) δ 1.49 (s, 9H), 2.17 (s, 1H), 4.53 (s, 2H), 6.83 (s, 1H), 7.19 (d, J = 8.5 Hz, 2H), 7.28 (d, J = 8.2 Hz, 2H); 13C NMR (CDCl3) δ 28.28, 64.54, 80.37, 118.49, 127.59, 135.31, 137.46, 152.72.

References

[1] Patent: WO2008/34124, 2008, A2. Location in patent: Page/Page column 72-73
[2] Patent: WO2006/31806, 2006, A2. Location in patent: Page/Page column 99
[3] Research on Chemical Intermediates, 2017, vol. 43, # 3, p. 1355 - 1363
[4] Tetrahedron Letters, 2007, vol. 48, # 51, p. 9044 - 9047
[5] Journal of Medicinal Chemistry, 1992, vol. 35, # 22, p. 4150 - 4159

BOC-4-AMINOBENZYLALCOHOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-4-AMINOBENZYLALCOHOL manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: BOC-4-AMINOBENZYLALCOHOL 144072-29-7
Price: US $75.00-750.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-06

Career Henan Chemical Co

Product: BOC-4-AMINOBENZYLALCOHOL 144072-29-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-30

144072-29-7, BOC-4-AMINOBENZYLALCOHOLRelated Search:

BOC-4-ABZ-OH 6-(BOC-AMINO)-1-HYDROXY-2,1-BENZOXABOROLANE 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid 1-(4-BOC-AMINO-PHENYL)-ETHANOL DI-BOC-3,4-DIAMINOBENZOIC ACID 3-AMINO-4-TERT-BUTOXYCARBONYLAMINO-BENZOIC ACID METHYL ESTER BOC-4-AMINO-3-METHOXYBENZOIC ACID BOC-4-ABZ-OSU TERT-BUTYL 4-(METHOXYCARBONYL)-3-METHOXYPHENYLCARBAMATE N-BOC-4-(METHYLAMINO)BENZOIC ACID N-BOC-4-AMINO-2-CHLOROBENZOIC ACID BOC-4-AMINO-3-METHYLBENZOIC ACID BOC-4-AMINOBENZYLALCOHOL 3-AMINO-4-TERT-BUTOXYCARBONYLAMINO-BENZOIC ACID ETHYL 4-(TERT-BUTOXYCARBONYLAMINO)BENZOATE 4-AMINO-3-(FMOC-AMINOMETHYL)-BENZOIC ACID 2,3-DIMETHYL-3,4-DIHYDRO-2H-QUINOXALINE-1,6-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER BUTTPARK 120\07-94

TERT-BUTYL 4-(HYDROXYMETHYL)PHENYLCARBAMATE

BOC-4-AMINOBENZYLALCOHOL

CarbaMic acid N-[4-(hydroxyMethyl)phenyl]-1,1-diMethyl ester

4-(Boc-aMino)benzyl alcohol

tert-butyl N-[4-(hydroxyMethyl)phenyl]carbaMate

tert-Butyl (4-(hydroxymethyl)

4-<N-(tertbutoxycarbonyl)amino>benzyl alcohol

Carbamic acid, N-[4-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester

144072-29-7

CMLLYL