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PF-06726304

Product Name
PF-06726304
CAS No.
1616287-82-1
Chemical Name
PF-06726304
Synonyms
PF-6726304;PF-06726304;antitumor,H3K27me3,PF06726304,Karpas-422,EZH2,PF 06726304,Histone Methyltransferase,inhibit,Inhibitor,PF-06726304,Y641N;5,8-dichloro-2-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(3,5-dimethylisoxazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one,;1(2H)-Isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-;5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
CBNumber
CB53353528
Molecular Formula
C22H21Cl2N3O3
Formula Weight
446.33
MOL File
1616287-82-1.mol
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PF-06726304 Property

Boiling point:
686.8±55.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO : ≥ 15 mg/mL (33.61 mM)
form 
powder
pka
11.76±0.10(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0346
Product name
PF-06726304 acetate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$114
Updated
2024/03/01
Tocris
Product number
6169
Product name
PF-06726304 acetate
Purity
≥97%(HPLC)
Packaging
10
Price
$173
Updated
2021/12/16
ChemScene
Product number
CS-8072
Product name
PF-06726304
Purity
99.64%
Packaging
5mg
Price
$92
Updated
2021/12/16
ChemScene
Product number
CS-8072
Product name
PF-06726304
Purity
99.64%
Packaging
10mg
Price
$156
Updated
2021/12/16
ChemScene
Product number
CS-8072
Product name
PF-06726304
Purity
99.64%
Packaging
25mg
Price
$360
Updated
2021/12/16
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PF-06726304 Chemical Properties,Usage,Production

Biochem/physiol Actions

PF-06726304 is a selective inhibitor of Histone-lysine N-methyltransferase EZH2 (enhancer of Zeste homolog 2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27) and is amplified and/or overexpressed in several human cancers including breast, prostate and lymphoma. PF-06726304 is a novel structural class of EZH2 inhibitor.

PF-06726304 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06726304 Suppliers

China 33 United States 5 Global 38
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32080
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38470
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

1616287-82-1, PF-06726304Related Search:


  • PF-06726304
  • 5,8-dichloro-2-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(3,5-dimethylisoxazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one,
  • 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
  • PF-6726304
  • 1(2H)-Isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-
  • antitumor,H3K27me3,PF06726304,Karpas-422,EZH2,PF 06726304,Histone Methyltransferase,inhibit,Inhibitor,PF-06726304,Y641N
  • 1616287-82-1