Phe-Met-Arg-Phe amide trifluoroacetate
- Product Name
- Phe-Met-Arg-Phe amide trifluoroacetate
- CAS No.
- 159237-99-7
- Chemical Name
- Phe-Met-Arg-Phe amide trifluoroacetate
- Synonyms
- Phe-Met-Arg-Phe amide trifluoroacetate;PHE-MET-ARG-PHE AMIDE TRIFLUOROACETATE?, >98%;Phe-Met-Arg-Phe amide trifluoroacetate,Phe-Met-Arg-Phe-NH2 trifluoroacetate,FMRF-NH2 trifluoroacetate?, >98%
- CBNumber
- CB53356170
- Molecular Formula
- C31H43F3N8O6S
- Formula Weight
- 712.79
- MOL File
- 159237-99-7.mol
Phe-Met-Arg-Phe amide trifluoroacetate Property
- storage temp.
- Store at -20°C
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water : ≥ 50 mg/mL (60.47 mM)
- Sequence
- H-Phe-Met-Arg-Phe-NH2
N-Bromosuccinimide Price
- Product number
- CS-7708
- Product name
- Phe-Met-Arg-Pheamidetrifluoroacetate
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- CS-7708
- Product name
- Phe-Met-Arg-Pheamidetrifluoroacetate
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $144
- Updated
- 2021/12/16
- Product number
- CS-7708
- Product name
- Phe-Met-Arg-Pheamidetrifluoroacetate
- Purity
- ≥98.0%
- Packaging
- 25mg
- Price
- $228
- Updated
- 2021/12/16
Phe-Met-Arg-Phe amide trifluoroacetate Chemical Properties,Usage,Production
Uses
Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K+ current, with ED50 of 23 nM in the peptidergic caudodorsal neurons.
in vivo
Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min[3].
References
[1] Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. DOI:10.1085/jgp.110.5.611
[2] Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. DOI:10.1016/0196-9781(84)90021-4
[3] Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7. DOI:10.1016/0143-4179(87)90054-0
Phe-Met-Arg-Phe amide trifluoroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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