Chloro(4-cyanophenyl){(R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl (dicyclohexylphosphine)}nickel(II) Property

form 

solid

color 

orange

Safety

RIDADR 

UN 3175 4.1 / PGII

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

Chloro(4-cyanophenyl){(R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl (dicyclohexylphosphine)}nickel(II) Chemical Properties,Usage,Production

Uses

1. Versatile air-stable low cost nickel catalyst alternative to palladium for carbon-carbon and carbonheteroatom cross-coupling reactions.
2. Used to react substituted aryl and heteroaryl halides and tosylates with ammonia to produce diverse aryl and heteroaryl amines.
3. Used in monoarylation experiments using commercially available ammonia gas, ammonium salts or ammonia stock solutions.
4. Catalyzes the coupling of aryl chlorides with gaseous amines in the form of their hydrochloride salts.

Uses

Amination of aryl chlorides, bromides and sulfonates with ammonia. Amination of aryl carbamates with ammonia or ammonium salts.

reaction suitability

core: nickel
reaction type: Cross Couplings
reagent type: catalyst
reaction type: Asymmetric synthesis