BI 882370
- Product Name
- BI 882370
- CAS No.
- 1392429-79-6
- Chemical Name
- BI 882370
- Synonyms
- CS-2615;BI 882370;BI882370;BI-882370;BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370;1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-;N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
- CBNumber
- CB53358255
- Molecular Formula
- C28H33F2N7O2S
- Formula Weight
- 569.67
- MOL File
- 1392429-79-6.mol
BI 882370 Property
- Boiling point:
- 649.6±65.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:5.0(Max Conc. mg/mL);8.78(Max Conc. mM)
- form
- A crystalline solid
- pka
- 5.48±0.10(Predicted)
- color
- Off-white to gray
N-Bromosuccinimide Price
- Product number
- 24273
- Product name
- BI-882370
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 24273
- Product name
- BI-882370
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 24273
- Product name
- BI-882370
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 24273
- Product name
- BI-882370
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- CS-0030522
- Product name
- BI-882370
- Purity
- 99.16%
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
BI 882370 Chemical Properties,Usage,Production
Description
BI-882370 is an orally bioavailable RAF inhibitor with IC50 values of 0.8, 0.8, and 0.6 nM for B-RAFV600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC50s = 49, 415, 485, 750, 715, and 1,220 nM, respectively). It inhibits proliferation of human B-RAF-mutant melanoma cells when used at concentrations ranging from 1 to 10 nM. It reduces tumor growth in multiple B-RAF-mutant melanoma and colorectal carcinoma mouse xenograft models when administered at a dose of 25 mg/kg twice per day. BI-882370, alone and in combination with trametinib , induces tumor regression in an A375 melanoma mouse xenograft model with no resistance developing within three or five weeks, respectively.
BI 882370 Preparation Products And Raw materials
Raw materials
Preparation Products
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