Ripretinib
- Product Name
- Ripretinib
- CAS No.
- 1442472-39-0
- Chemical Name
- Ripretinib
- Synonyms
- KIT/PDGFR INHIBITOR(DCC-2618);Ripretinib (DCC-2618);Ripretinib;DCC-2618 HCl;1442472-39-0;13C6]-Ripretinib;KIT/PDGFR inhibitor;Ripretinib USP/EP/BP;Ripretinib Impurity 3;Oliceridine Impurity 17
- CBNumber
- CB53365156
- Molecular Formula
- C24H21BrFN5O2
- Formula Weight
- 510.36
- MOL File
- 1442472-39-0.mol
Ripretinib Property
- Boiling point:
- 568.6±50.0 °C(Predicted)
- Density
- 1.544±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:25.0(Max Conc. mg/mL);49.0(Max Conc. mM)
- form
- A solid
- pka
- 12.15±0.70(Predicted)
- color
- White to light yellow
- InChIKey
- CEFJVGZHQAGLHS-UHFFFAOYSA-N
- SMILES
- N(C1=CC(C2=CC3=C(N(CC)C2=O)C=C(NC)N=C3)=C(Br)C=C1F)C(NC1=CC=CC=C1)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0044835
- Product name
- Ripretinib
- Purity
- 98.90%
- Packaging
- 5mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- CS-0044835
- Product name
- Ripretinib
- Purity
- 98.90%
- Packaging
- 10mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- orb573361
- Product name
- Ripretinib (DCC-2618)
- Purity
- >98%
- Packaging
- 100mg
- Price
- $986
- Updated
- 2021/12/16
- Product number
- CS-0044835
- Product name
- Ripretinib
- Purity
- 98.90%
- Packaging
- 50mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- CS-0044835
- Product name
- Ripretinib
- Purity
- 98.90%
- Packaging
- 100mg
- Price
- $1850
- Updated
- 2021/12/16
Ripretinib Chemical Properties,Usage,Production
Uses
Ripretinib is used in the treatment of gastrointestinal stromal tumors (GISTs).
brand name
Qinlock
General Description
Class: receptor tyrosine kinase; Treatment: GIST; Other name: DCC-2618; Elimination half-life = 15 h; Protein binding = 98.8%
Biological Activity
Ripretinib is a highly effective inhibitor of both wild-type KIT and PDGFRA, with IC50 values around 3 nM. It also targets a wide range of KIT and PDGFRA mutants in GIST. Additionally, it inhibits various tumor-driving kinases such as PDGFRβ, TIE2, VEGFR2, and BRAF.
Synthesis
The diethyl ester 297 was reacted with triethyl orthoformate and acetic anhydride by heating. Subsequent addition of aqueous ammonia afforded pyridine 298. Pyridine 298 was treated neat with phosphorus oxychloride at reflux to afford dichloride 299 in 90% yield. The 4-chloro group of pyridine 299 was selectively replaced by ethylamine in cooled acetonitrile to afford the product. Oxidation state adjustment using lithium aluminum hydride followed by MnO2 afforded 4-aminopyridine 300. Starting from acid 301, a three-step reaction process involving nitration, esterification, and reduction provided ester 302 directly. Ester 302 reacted with intermediate 300 in DMA (N,N-dimethylacetamide) with the aid of KF on alumina to form naphthyridinone ring system 303 via Knoevenagel cyclization. Methylamine groups were installed on naphthyridinone ring system 303. Reaction with phenylisocyanate to form urea completed the preparation of ripretinib.
target
Primary targets: PDGFRA, KIT
Ripretinib Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ripretinib manufacturers
- Product
- Ripretinib 1442472-39-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-07-19
- Product
- Ripretinib. 1442472-39-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-12-31
- Product
- Ripretinib 1442472-39-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-17