DDR1-IN-2

Uses

Product Name: DDR1-IN-2
CAS No.: 1429617-90-2
Chemical Name: DDR1-IN-2
Synonyms: 7rh;DDR1-IN-2;DDR1 Inhibitor 7rh;DDR1 Inhibitor 7rh >=98% (HPLC);DDR1 IN 2,Discoidin Domain Receptor,Inhibitor,7rh,inhibit,DDR-1-IN-2,DDR1IN2;4-Ethyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide;4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE;Benzamide, 4-ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)-
CBNumber: CB53367620
Molecular Formula: C30H29F3N6O
Formula Weight: 546.59
MOL File: 1429617-90-2.mol

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DDR1-IN-2 Property

storage temp.: 2-8°C
solubility: DMSO: 62.5 mg/mL (114.35 mM)
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1832
Product name: DDR1 Inhibitor 7rh
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1832
Product name: DDR1 Inhibitor 7rh
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $217.2
Updated: 2024/03/01

ChemScene

Product number: CS-0035397
Product name: DDR1-IN-2
Purity: 98.62%
Packaging: 25mg
Price: $740
Updated: 2021/12/16

Activate Scientific

Product number: AS117230
Product name: DDR1-IN-2
Purity: 97+%
Packaging: 5mg
Price: $163
Updated: 2021/12/16

ChemScene

Product number: CS-0035397
Product name: DDR1-IN-2
Purity: 98.62%
Packaging: 5mg
Price: $210
Updated: 2021/12/16

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DDR1-IN-2 Chemical Properties,Usage,Production

Uses

7rh is a useful research chemical compound.

Uses

7rh is a discoidin domain receptor 1 (DDR1) inhibitor useful in the study of similar derivatives as potential anticancer and anti-??inflammatory drugs.

General Description

DDR1 Inhibitor 7rh is a small potent kinase inhibitor of discoidin domain receptor-1 (DDR1). It inhibits the tumorigenicity of nasopharyngeal carcinoma (NPC) cells. DDR1 Inhibitor 7rh prevents the proliferation, invasion and adhesion of cancer cells.

Biochem/physiol Actions

DDR1 Inhibitor 7rh is an orally available, potent, ATP-competitive DDR1-selective inhibitor with in vitro and in vivo anti-cancer efficacy. Compound 7rh is a potent, high affinity (Kd =0.6 nM), ATP-competitive inhibitor against discoidin domain-containing receptor 1 (DDR1; IC50 = 6.8 nM, [ATP] = 100 nM) with significantly reduced potency toward 455 other kinases, including DDR2, Bcr-abl, and c-Kit (IC50 = 101.4 nM, 355 nM and >10 μM, respectively). Inhibitor 7rh reduces DDR1 expression/phosphorylation and downstream signaling in a dose-dependent manner (0.1-2 μM; NCI-H23 NSCLCs), effectively suppressing human cancer cells proliferation (IC50 from 38 nM/K562 to 2.98 μM/NCI-H460) and colony formation (IC50 = 0.56 μM/NCI-H23). Inhibitor 7rh is orally availabe in rats and mice (T1/2 = 15.53 h; Tmax = 4.25 h; Cmax = 1867.5 μg/L, F = 67.4%; 25 mg/kg; rats) and displays in vivo efficacy against Kras (LSLG12Vgeo) tumor growth in mice (50 mg/kg/day p.o.).

storage

Store at -20°C

DDR1-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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DDR1-IN-2 Suppliers

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1429617-90-2, DDR1-IN-2Related Search:

4-Ethyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide

4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE

DDR1-IN-2

DDR1 Inhibitor 7rh

Benzamide, 4-ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)-

DDR1 Inhibitor 7rh >=98% (HPLC)

7rh

DDR1 IN 2,Discoidin Domain Receptor,Inhibitor,7rh,inhibit,DDR-1-IN-2,DDR1IN2

1429617-90-2

C30H29F3N6O