ChemicalBook > CAS DataBase List > E3 ligase Ligand-Linker Conjugates 5
E3 ligase Ligand-Linker Conjugates 5
- Product Name
- E3 ligase Ligand-Linker Conjugates 5
- CAS No.
- 2097971-11-2
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 5
- Synonyms
- VH032-PEG3-NH2 hydrochloride;(S,R,S)-AHPC-PEG3-NH2 hydrochloride;E3 ligase Ligand-Linker Conjugates 5;(S,R,S)-AHPC-PEG3-NH2 hydrochloride >=95%;VHL Ligand-Linker Conjugates 1 hydrochloride;(S,R,S)-AHPC-PEG3-NH2 hydrochloride（E3 ligase Ligand-Linker Conjugates 5）;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2R,4S)-1-((R)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
- CBNumber
- CB53386472
- Molecular Formula
- C30H46ClN5O7S
- Formula Weight
- 656.24
- MOL File
- 2097971-11-2.mol
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E3 ligase Ligand-Linker Conjugates 5 Property
- storage temp.
- 2-8°C
- form
- powder or crystals
- color
- Light yellow to brown
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Safety
- HS Code
- 2934100090
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 901511
- Product name
- (S,R,S)-AHPC-PEG3-NH2 hydrochloride
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $326
- Updated
- 2024/03/01
Iris Biotech GmbH
- Product number
- PTC1330
- Product name
- (S,R,S)-AHPC-PEG3-NH2 hydrochloride
- Packaging
- 50mg
- Price
- $499.5
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN23963
- Product name
- VHL032-keto-PEG3-C2-amine HCl
- Packaging
- 25mg
- Price
- $149
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN23963
- Product name
- VHL032-keto-PEG3-C2-amine HCl
- Packaging
- 100mg
- Price
- $326
- Updated
- 2021/12/16
DC Chemicals
- Product number
- 027599
- Product name
- (S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5）
- Packaging
- 001
- Price
- $500
- Updated
- 2021/12/16
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E3 ligase Ligand-Linker Conjugates 5 Chemical Properties,Usage,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG3-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
E3 ligase Ligand-Linker Conjugates 5 Preparation Products And Raw materials
Raw materials
Preparation Products
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E3 ligase Ligand-Linker Conjugates 5 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 5 manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- (S,R,S)-AHPC-PEG3-NH2 hydrochloride 2097971-11-2
- Price
- US $0.00/mg
- Min. Order
- 250mg
- Purity
- >98.00%
- Supply Ability
- 250mg
- Release date
- 2024-04-01