JT010
- Product Name
- JT010
- CAS No.
- 917562-33-5
- Chemical Name
- JT010
- Synonyms
- JT010;2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide;2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide;Acetamide, 2-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)-;JT010,JT-010,TRP Channel,Transient receptor potential channels,inhibit,Inhibitor,JT 010
- CBNumber
- CB53386492
- Molecular Formula
- C16H19ClN2O3S
- Formula Weight
- 354.85
- MOL File
- 917562-33-5.mol
JT010 Property
- Boiling point:
- 487.4±55.0 °C(Predicted)
- Density
- 1.265±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- powder
- pka
- 2.59±0.10(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1672
- Product name
- JT010
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2023/06/20
- Product number
- SML1672
- Product name
- JT010
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2023/06/20
- Product number
- 29732
- Product name
- JT010
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 29732
- Product name
- JT010
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 29732
- Product name
- JT010
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
JT010 Chemical Properties,Usage,Production
Description
JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC50 = 0.65 nM in a calcium influx assay). It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 μM.
Uses
JT010 is a potent and selective TRPA1 channel activator (EC50 = 65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).
Biochem/physiol Actions
JT010 is a non-cytotoxic and highly stable (>90% remains after 2 h in 1 mM DTT or 2-mercaptoethanol) chloroacetamido warhead-carrying thiazole derivative that acts as a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC50?= 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50?>1 μM).
storage
Store at +4°C
JT010 Preparation Products And Raw materials
Raw materials
Preparation Products
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