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JT010

Product Name
JT010
CAS No.
917562-33-5
Chemical Name
JT010
Synonyms
JT010;2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide;2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide;Acetamide, 2-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)-;JT010,JT-010,TRP Channel,Transient receptor potential channels,inhibit,Inhibitor,JT 010
CBNumber
CB53386492
Molecular Formula
C16H19ClN2O3S
Formula Weight
354.85
MOL File
917562-33-5.mol
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JT010 Property

Boiling point:
487.4±55.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
powder
pka
2.59±0.10(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1672
Product name
JT010
Purity
≥98% (HPLC)
Packaging
5MG
Price
$105
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1672
Product name
JT010
Purity
≥98% (HPLC)
Packaging
25MG
Price
$424
Updated
2023/06/20
Cayman Chemical
Product number
29732
Product name
JT010
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
29732
Product name
JT010
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29732
Product name
JT010
Packaging
10mg
Price
$166
Updated
2024/03/01
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JT010 Chemical Properties,Usage,Production

Description

JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC50 = 0.65 nM in a calcium influx assay). It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 μM.

Uses

JT010 is a potent and selective TRPA1 channel activator (EC50 = 65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).

Biochem/physiol Actions

JT010 is a non-cytotoxic and highly stable (>90% remains after 2 h in 1 mM DTT or 2-mercaptoethanol) chloroacetamido warhead-carrying thiazole derivative that acts as a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC50?= 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50?>1 μM).

storage

Store at +4°C

JT010 Preparation Products And Raw materials

Raw materials

Preparation Products

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JT010 Suppliers

China 35 United Kingdom 1 United States 4 Global 40
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58

917562-33-5, JT010Related Search:


  • JT010
  • 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide
  • Acetamide, 2-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)-
  • 2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide
  • JT010,JT-010,TRP Channel,Transient receptor potential channels,inhibit,Inhibitor,JT 010
  • 917562-33-5