ChemicalBook > CAS DataBase List > sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate

sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate

Product Name
sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
CAS No.
496807-11-5
Chemical Name
sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
Synonyms
Beraprost impurity 27;Beraprost Impurity 10 Sodium Salt;Beraprost Sodium (Mixture of Diastereomers);Beraprost sodium (Relative stereochemistry);sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
CBNumber
CB53400703
Molecular Formula
C24H31NaO5
Formula Weight
422.5
MOL File
496807-11-5.mol
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sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate Property

storage temp. 
Store at -20°C
solubility 
DMSO: 250 mg/mL (594.57 mM)
form 
Solid
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0007214
Product name
Beraprost(sodium)
Purity
99.88%
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0007214
Product name
Beraprost(sodium)
Purity
99.88%
Packaging
10mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0007214
Product name
Beraprost(sodium)
Purity
99.88%
Packaging
25mg
Price
$950
Updated
2021/12/16
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sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate Chemical Properties,Usage,Production

Biological Activity

Beraprost sodium, a prostacyclin analog, is a stable and orally active PGI2 prodrug. It is an effective vasodilator, which has the potential to study pulmonary hypertension by dilating renal blood vessels and improving microcirculation.

in vitro

Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment leads to a significant increase in the number of tube formation, BPS plays an important role on angiogenic activity. Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment let VE-cadherin at regions of cell–cell contact becomes more abundant and the morphology of endothelial cells tends to be normal compared with those cultured under hypoxia conditions.

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in vivo

Beraprost sodium (oral adminstration; 0.6 mg/kg; once daily; 3 or 7 days) can mitigate the development of renal interstitial fibrosis, decrease renal oxidative stress through its potential vasodilation effect, and further prevent renal interstitial fibrosis .

Animal Model: 6-8-week-old C57Bl/6J Male Mice
Dosage: 0.6 mg/kg
Administration: Oral adminstration; 0.6 mg/kg; once daily; 3 or 7 days
Result: < /td> Mitigated the development of renal interstitial fibrosis.

target

prodrug of PGI2; Vasodilator

storage

Store at -20°C

sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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496807-11-5, sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoateRelated Search:

Beraprost Impurity 4 Beraprost methyl ester Beraprost sodium Beraprost Impurity 3 Beraprost Impurity 2 Beraprost (8S,9S,16S) Isomer Beraprost 15-R isomer Sodium Salt Beraprost (8S,9S,16R) Isomer Beraprost Impurity 1

  • sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
  • Beraprost sodium (Relative stereochemistry)
  • Beraprost Impurity 10 Sodium Salt
  • Beraprost impurity 27
  • Beraprost Sodium (Mixture of Diastereomers)
  • 496807-11-5