Beraprost sodium

Product Name: Beraprost sodium
CAS No.: 88475-69-8
Chemical Name: Beraprost sodium
Synonyms: BERAPROST SODIUM SALT;Dorner;ML 1129;TRK 100;Berasus;PROCYLIN;Careload;Procyclin;MDL 201129;Befraprost
CBNumber: CB8761736
Molecular Formula: C24H29NaO5
Formula Weight: 420.47
MOL File: 88475-69-8.mol

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Beraprost sodium Property

Melting point:: 204-206°C
storage temp.: -20°C
solubility: DMF:77.0(Max Conc. mg/mL);183.12(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);47.56(Max Conc. mM)
PBS (pH 7.2):19.0(Max Conc. mg/mL);45.19(Max Conc. mM)
form: powder
color: white to beige
CAS DataBase Reference: 88475-69-8(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1737
Product name: Beraprost sodium
Purity: ≥98% (HPLC)
Packaging: 1MG
Price: $135
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1737
Product name: Beraprost sodium
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $542
Updated: 2023/06/20

Cayman Chemical

Product number: 18230
Product name: Beraprost (sodium salt)
Purity: ≥98%
Packaging: 1mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 18230
Product name: Beraprost (sodium salt)
Purity: ≥98%
Packaging: 5mg
Price: $540
Updated: 2024/03/01

Cayman Chemical

Product number: 18230
Product name: Beraprost (sodium salt)
Purity: ≥98%
Packaging: 10mg
Price: $945
Updated: 2024/03/01

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Beraprost sodium Chemical Properties,Usage,Production

Description

Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP in platelets which is achieved by activating adenylate cyclase in the platelet membrane, followed by the inhibition ofCa⁺⁺- influx and thromboxane A2 formation.

Description

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 μg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension. Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.

Chemical Properties

White Solid

Originator

Toray (Japan)

Uses

Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).

Definition

ChEBI: Beraprost sodium is the organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, a prostaglandin receptor agonist, a vasodilator agent and an anti-inflammatory agent. It contains a beraprost(1-).

brand name

Dorner; Dorner;Procylin

General Description

Beraprost sodium is an orally active prostacyclin analog.

Biochem/physiol Actions

Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.

Beraprost sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Beraprost sodium Suppliers

Canada 1 China 112 Europe 2 India 3 United Kingdom 2 United States 12 Global 132

Shanghai finete Pharmaceutical Co., Ltd.

Tel: 021-021-00000000 18221039705
Fax: QQ:17263424
Email: finetechpharm@126.com
Country: China
ProdList: 180
Advantage: 58

BEIJING QIONGFENG TECHNOLOGICAL CO., LTD.

Tel: 13552142508
Email: 766912840@qq.com
Country: China
ProdList: 233
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 0712-0712-2580635 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: SALES@UHNSHANGHAI.COM
Country: China
ProdList: 977
Advantage: 58

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

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View Lastest Price from Beraprost sodium manufacturers

Shanghai Getian Industrial Co., LTD

Product: Beraprost sodium 88475-69-8
Price: US $21.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 10000box
Release date: 2024-04-28

Hebei Weimiao Import and Export Trade Co., Ltd.

Product: Beraprost Sodium 88475-69-8
Price: US $40.00-36.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200000
Release date: 2024-02-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Beraprost sodium 88475-69-8
Price: US $0.00/g
Min. Order: 100mg
Purity: 98.5%-101%
Supply Ability: 10G
Release date: 2021-07-20

88475-69-8, Beraprost sodiumRelated Search:

CHLOROPHOSPHONAZO III Sodium carbonate Methanol Sodium hydroxide Prostaglandin E1 Glycolic acid Latanoprost Sodium acetate Diclofenac sodium Sodium benzoate Cloprostenol sodium Hydroxy silicone oil Epoprostenol Sodium formate Acetonitrile Prostaglandin E2 Nitrofurantoin Sodium bicarbonate

beraprostsodium

ML 1129

PROCYLIN

TRK 100

BERAPROST SODIUM SALT

2,3,3A-8B-TETRAHYDRO-2-HYDROXY-1-(3-HYDROXY-4-METHYL-1-OCTEN-6-YNYL)-1H-CYCLOPENTA[B]BENZOFURAN-5-BUTANOIC ACID, SODIUM SALT

1H-Cyclopenta[b]benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-, monosodium salt

Dorner

MDL 201129

Procyclin

2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt

dl-4-[(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-[(3S,4RS)-3-hydroxy-4-Methyl-oct-6-yne-(E)-1-enyl]-5-cyclopenta[b]benzofuranyl]butanoic Acid SodiuM

Berasus

Careload

Sodium 2,3,3a-8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoate

Befraprost

Unii-15K99vdu5f

Beraprost sodium###Beraprost

Beprostaglandin sodium

sodium 4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl]butanoate

Beraprost sodium USP/EP/BP

Sodium (E)-4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate (Beraprost Impurity)

Sodium 4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate

Beraprost sodium impurity

sodium,4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate

88475-69-8

C24H29O5Na

C24H29NaO5

Prostaglandin

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Prostaglandins