Beraprost sodium

ChemicalBook > CAS DataBase List > Beraprost sodium

Product Name: Beraprost sodium
CAS No.: 88475-69-8
Chemical Name: Beraprost sodium
Synonyms: BERAPROST SODIUM SALT;Dorner;ML 1129;TRK 100;Berasus;PROCYLIN;Careload;Procyclin;MDL 201129;Befraprost
CBNumber: CB8761736
Molecular Formula: C24H29NaO5
Formula Weight: 420.47
MOL File: 88475-69-8.mol

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Beraprost sodium Property

Melting point:: 204-206°C
storage temp.: -20°C
solubility: DMF:77.0(Max Conc. mg/mL);183.12(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);47.56(Max Conc. mM)
PBS (pH 7.2):19.0(Max Conc. mg/mL);45.19(Max Conc. mM)
form: powder
color: white to beige
InChI: InChI=1/C24H30O5.Na/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28;/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28);/q;+1/p-1/b13-12+;/t15?,17-,19+,20+,21-,23-;/s3
InChIKey: YTCZZXIRLARSET-LIIFYGAANA-M
SMILES: [C@H]12[C@H](C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C(C)CC#CC)OC1C(=CC=CC2=1)CCCC([O-])=O.[Na+] |&1:0,1,3,5,8,r|
CAS DataBase Reference: 88475-69-8(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1737
Product name: Beraprost sodium
Purity: ≥98% (HPLC)
Packaging: 1MG
Price: $135
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1737
Product name: Beraprost sodium
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $542
Updated: 2023/06/20

Cayman Chemical

Product number: 18230
Product name: Beraprost (sodium salt)
Purity: ≥98%
Packaging: 1mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 18230
Product name: Beraprost (sodium salt)
Purity: ≥98%
Packaging: 5mg
Price: $540
Updated: 2024/03/01

Cayman Chemical

Product number: 18230
Product name: Beraprost (sodium salt)
Purity: ≥98%
Packaging: 10mg
Price: $945
Updated: 2024/03/01

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Beraprost sodium Chemical Properties,Usage,Production

Description

Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP in platelets which is achieved by activating adenylate cyclase in the platelet membrane, followed by the inhibition ofCa⁺⁺- influx and thromboxane A2 formation.

Description

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 μg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension. Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.

Chemical Properties

White Solid

Originator

Toray (Japan)

Uses

Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).

Definition

ChEBI: Beraprost sodium is the organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, a prostaglandin receptor agonist, a vasodilator agent and an anti-inflammatory agent. It contains a beraprost(1-).

brand name

Dorner; Dorner;Procylin

General Description

Beraprost sodium is an orally active prostacyclin analog.

Biochem/physiol Actions

Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.

Side effects

Disease-related events had similar incidence in patients receiving beraprost and those receiving placebo. Drug-related adverse events like headache, flushing, jaw pain, and diarrhea were more common in patients treated with beraprost sodium and occurred mostly during the six-week titration period. The incidence was markedly reduced in the maintenance period. Six patients (9%) in the beraprost sodium group and two (3%) in the placebo group withdrew prematurely from the study because of adverse events. No clinically adverse changes in hematologic or biochemical variables were seen in the beraprost sodium group.

Beraprost sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Beraprost sodium manufacturers

Shanghai Getian Industrial Co., LTD

Product: Beraprost sodium 88475-69-8
Price: US $21.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 10000box
Release date: 2024-04-28

Hebei Weimiao Import and Export Trade Co., Ltd.

Product: Beraprost Sodium 88475-69-8
Price: US $40.00-36.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200000
Release date: 2024-02-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Beraprost sodium 88475-69-8
Price: US $0.00/g
Min. Order: 100mg
Purity: 98.5%-101%
Supply Ability: 10G
Release date: 2021-07-20

88475-69-8, Beraprost sodiumRelated Search:

CHLOROPHOSPHONAZO III Sodium carbonate Methanol Sodium hydroxide Prostaglandin E1 Glycolic acid Latanoprost Sodium acetate Diclofenac sodium Sodium benzoate Cloprostenol sodium Hydroxy silicone oil Epoprostenol Sodium formate Acetonitrile Prostaglandin E2 Nitrofurantoin Sodium bicarbonate

beraprostsodium

ML 1129

PROCYLIN

TRK 100

BERAPROST SODIUM SALT

2,3,3A-8B-TETRAHYDRO-2-HYDROXY-1-(3-HYDROXY-4-METHYL-1-OCTEN-6-YNYL)-1H-CYCLOPENTA[B]BENZOFURAN-5-BUTANOIC ACID, SODIUM SALT

1H-Cyclopenta[b]benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-, monosodium salt

Dorner

MDL 201129

Procyclin

2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt

dl-4-[(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-[(3S,4RS)-3-hydroxy-4-Methyl-oct-6-yne-(E)-1-enyl]-5-cyclopenta[b]benzofuranyl]butanoic Acid SodiuM

Berasus

Careload

Sodium 2,3,3a-8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoate

Befraprost

Unii-15K99vdu5f

Beraprost sodium###Beraprost

Beprostaglandin sodium

sodium 4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl]butanoate

Beraprost sodium USP/EP/BP

Sodium (E)-4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate (Beraprost Impurity)

Sodium 4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate

Beraprost sodium impurity

sodium,4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate

88475-69-8

C24H29O5Na

C24H29NaO5

Prostaglandin

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Prostaglandins