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Beraprost sodium

Product Name
Beraprost sodium
CAS No.
88475-69-8
Chemical Name
Beraprost sodium
Synonyms
BERAPROST SODIUM SALT;Dorner;ML 1129;TRK 100;Berasus;PROCYLIN;Careload;Procyclin;MDL 201129;Befraprost
CBNumber
CB8761736
Molecular Formula
C24H29NaO5
Formula Weight
420.47
MOL File
88475-69-8.mol
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Beraprost sodium Property

Melting point:
204-206°C
storage temp. 
-20°C
solubility 
DMF:77.0(Max Conc. mg/mL);183.12(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);47.56(Max Conc. mM)
PBS (pH 7.2):19.0(Max Conc. mg/mL);45.19(Max Conc. mM)
form 
powder
color 
white to beige
InChI
InChI=1/C24H30O5.Na/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28;/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28);/q;+1/p-1/b13-12+;/t15?,17-,19+,20+,21-,23-;/s3
InChIKey
YTCZZXIRLARSET-LIIFYGAANA-M
SMILES
[C@H]12[C@H](C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C(C)CC#CC)OC1C(=CC=CC2=1)CCCC([O-])=O.[Na+] |&1:0,1,3,5,8,r|
CAS DataBase Reference
88475-69-8(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1737
Product name
Beraprost sodium
Purity
≥98% (HPLC)
Packaging
1MG
Price
$135
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1737
Product name
Beraprost sodium
Purity
≥98% (HPLC)
Packaging
5MG
Price
$542
Updated
2023/06/20
Cayman Chemical
Product number
18230
Product name
Beraprost (sodium salt)
Purity
≥98%
Packaging
1mg
Price
$135
Updated
2024/03/01
Cayman Chemical
Product number
18230
Product name
Beraprost (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$540
Updated
2024/03/01
Cayman Chemical
Product number
18230
Product name
Beraprost (sodium salt)
Purity
≥98%
Packaging
10mg
Price
$945
Updated
2024/03/01
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Beraprost sodium Chemical Properties,Usage,Production

Description

Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP in platelets which is achieved by activating adenylate cyclase in the platelet membrane, followed by the inhibition ofCa++- influx and thromboxane A2 formation.

Description

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 μg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension. Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.

Chemical Properties

White Solid

Originator

Toray (Japan)

Uses

Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).

Definition

ChEBI: Beraprost sodium is the organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, a prostaglandin receptor agonist, a vasodilator agent and an anti-inflammatory agent. It contains a beraprost(1-).

brand name

Dorner; Dorner;Procylin

General Description

Beraprost sodium is an orally active prostacyclin analog.

Biochem/physiol Actions

Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.

Side effects

Disease-related events had similar incidence in patients receiving beraprost and those receiving placebo. Drug-related adverse events like headache, flushing, jaw pain, and diarrhea were more common in patients treated with beraprost sodium and occurred mostly during the six-week titration period. The incidence was markedly reduced in the maintenance period. Six patients (9%) in the beraprost sodium group and two (3%) in the placebo group withdrew prematurely from the study because of adverse events. No clinically adverse changes in hematologic or biochemical variables were seen in the beraprost sodium group.

Beraprost sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Beraprost sodium Suppliers

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View Lastest Price from Beraprost sodium manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Beraprost sodium 88475-69-8
Price
US $0.00/g
Min. Order
100mg
Purity
98.5%-101%
Supply Ability
10G
Release date
2021-07-20
Hebei Weimiao Import and Export Trade Co., Ltd.
Product
Beraprost Sodium 88475-69-8
Price
US $40.00-36.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200000
Release date
2024-02-22
Shanghai Getian Industrial Co., LTD
Product
Beraprost sodium 88475-69-8
Price
US $21.00/box
Min. Order
1box
Purity
99%
Supply Ability
10000box
Release date
2024-04-28

88475-69-8, Beraprost sodiumRelated Search:


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  • BERAPROST SODIUM SALT
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  • 1H-Cyclopenta[b]benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-, monosodium salt
  • Dorner
  • MDL 201129
  • Procyclin
  • 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt
  • dl-4-[(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-[(3S,4RS)-3-hydroxy-4-Methyl-oct-6-yne-(E)-1-enyl]-5-cyclopenta[b]benzofuranyl]butanoic Acid SodiuM
  • Berasus
  • Careload
  • Sodium 2,3,3a-8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoate
  • Befraprost
  • Unii-15K99vdu5f
  • Beraprost sodium###Beraprost
  • Beprostaglandin sodium
  • sodium 4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl]butanoate
  • Beraprost sodium USP/EP/BP
  • Sodium (E)-4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate (Beraprost Impurity)
  • Sodium 4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate
  • sodium,4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
  • Beraprost sodium impurity
  • 88475-69-8
  • C24H29O5Na
  • C24H29NaO5
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