(S)-2-HYDROXYBUTYRIC ACID
- Product Name
- (S)-2-HYDROXYBUTYRIC ACID
- CAS No.
- 3347-90-8
- Chemical Name
- (S)-2-HYDROXYBUTYRIC ACID
- Synonyms
- (S)-2-HYDROXYBUTYRIC;(S)-2-Hydroxybutyrate;Pemafibrate Impurity 4;L-2-HYDROXYBUTYRIC ACID;Lactic acid impurity 72;(S)-2-HYDROXYBUTYRIC ACID;(2S)-2-Hydroxybutyric acid;(S)-2-Hydroxybutanoic acid;(2S)-2-hydroxybutanoic acid;(S)-2-hydroxybutanoatic acid
- CBNumber
- CB5341672
- Molecular Formula
- C4H8O3
- Formula Weight
- 104.1
- MOL File
- 3347-90-8.mol
(S)-2-HYDROXYBUTYRIC ACID Property
- Melting point:
- 50-54 °C
- Boiling point:
- 238℃
- Density
- 1.195
- Flash point:
- 112℃
- storage temp.
- 2-8°C
- pka
- 3.83±0.10(Predicted)
- form
- solid
- color
- Pale yellow
- BRN
- 1720940
- InChI
- InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/t3-/m0/s1
- InChIKey
- AFENDNXGAFYKQO-VKHMYHEASA-N
- SMILES
- C(O)(=O)[C@@H](O)CC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 54918
- Product name
- (S)-2-Hydroxybutyric acid
- Purity
- for chiral derivatization, ≥97.0%
- Packaging
- 1G
- Price
- $358.15
- Updated
- 2025/07/31
- Product number
- H956328
- Product name
- (S)-2-HydroxybutanoicAcid
- Packaging
- 5g
- Price
- $550
- Updated
- 2021/12/16
- Product number
- E769
- Product name
- S-2-Hydroxybutyricacid
- Packaging
- 25g
- Price
- $901
- Updated
- 2021/12/16
- Product number
- CHM0005109
- Product name
- (S)-2-HYDROXYBUTYRATE
- Purity
- 95.00%
- Packaging
- 1KG
- Price
- $9944.55
- Updated
- 2021/12/16
- Product number
- P38746
- Product name
- (S)-2-Hydroxy-butanoicacid
- Purity
- 95%
- Packaging
- 500MG
- Price
- $95
- Updated
- 2021/12/16
(S)-2-HYDROXYBUTYRIC ACID Chemical Properties,Usage,Production
Chemical Properties
Off-white crystals or pale liquid
Uses
(S)-2-Hydroxybutanoic acid is used in method for preparing Cationic Electrodeposition coating compounds.
Definition
ChEBI: An optically active form of 2-hydroxybutyric acid having (S)-configuration.
Synthesis
1492-24-6
3347-90-8
The general procedure for the synthesis of (S)-2-hydroxybutyric acid from L-2-aminobutyric acid was as follows: (S)-2-aminobutyric acid (20.0 g, 194 mmol) was dissolved in 1N sulfuric acid solution (228 mL). Aqueous sodium nitrite solution (26.8 g, 338 mmol, 68 mL) was slowly added dropwise at -5 °C, and stirring of the reaction mixture was continued for 0.5 h after completion of the dropwise addition. Subsequently, the reaction mixture was warmed to room temperature and stirred continuously for 2 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and sulfuric acid was added to adjust the pH to 1. After adjusting the pH, the mixture was stirred for 12 hours at room temperature. Next, sodium chloride (120 g) and methyl tert-butyl ether (MTBE, 120 mL) were added to the reaction mixture and stirred for 30 min before MTBE extraction. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-2-hydroxybutyric acid (13.8 g, 69% yield) as a pale yellow solid. The product was characterized by 1H NMR (400 MHz, CDCl3), δ 1.00 (t, J=7.6 Hz, 3H), 1.68-1.79 (m, 1H), 1.84-1.93 (m, 1H), 4.24 (dd, J=6.8,4.4 Hz, 1H).
IC 50
Human Endogenous Metabolite
References
[1] Patent: US2016/60203, 2016, A1. Location in patent: Paragraph 0082; 0083
[2] Journal of Organic Chemistry, 1993, vol. 58, # 18, p. 4805 - 4808
[3] Journal of the American Chemical Society, 1951, vol. 73, p. 1336
[4] Journal of Biological Chemistry, 1941, vol. 141, p. 404
[5] Biochemische Zeitschrift, 1937, vol. 293, p. 410,412
(S)-2-HYDROXYBUTYRIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-2-HYDROXYBUTYRIC ACID manufacturers
- Product
- (S)-2-HYDROXYBUTYRIC ACID 3347-90-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 2000
- Release date
- 2025-09-25
- Product
- (S)-2-HYDROXYBUTYRIC ACID 3347-90-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-15
- Product
- (S)-2-HYDROXYBUTYRIC ACID 3347-90-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-18