ChemicalBook > CAS DataBase List > 5,7-Difluoroindole

5,7-Difluoroindole

Product Name: 5,7-Difluoroindole
CAS No.: 301856-25-7
Chemical Name: 5,7-Difluoroindole
Synonyms: SW-101;SWF-101;5,7-difluoroinde;5,8-Difluoroindole;5,7-DIFLUOROINDOLE;5,7-Difluoro-1H-Indole;1H-Indole, 5,7-difluoro-;1H-Indole,5,7-difluoro-(9CI)
CBNumber: CB5344431
Molecular Formula: C8H5F2N
Formula Weight: 153.13
MOL File: 301856-25-7.mol

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5,7-Difluoroindole Property

Boiling point:: 253.2±20.0 °C(Predicted)
Density: 1.388±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.71±0.30(Predicted)
form: liquid
color: Light yellow
InChI: InChI=1S/C8H5F2N/c9-6-3-5-1-2-11-8(5)7(10)4-6/h1-4,11H
InChIKey: WZPOGQRJXZGSMH-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(F)C=C2F)C=C1
CAS DataBase Reference: 301856-25-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D452068
Product name: 5,7-Difluoroindole
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC7807
Product name: 5,7-Difluoro-1H-indole
Packaging: 250mg
Price: $79
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-3-Q1
Product name: 5,7-Difluoro-1H-indole
Packaging: 250mg
Price: $87
Updated: 2021/12/16

ChemScene

Product number: CS-W022280
Product name: 5,7-Difluoro-1H-indole
Purity: 99.35%
Packaging: 250mg
Price: $91
Updated: 2021/12/16

Apolloscientific

Product number: PC7807
Product name: 5,7-Difluoro-1H-indole
Packaging: 1g
Price: $198
Updated: 2021/12/16

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5,7-Difluoroindole Chemical Properties,Usage,Production

Synthesis

500139-00-4

301856-25-7

Example 4: Synthesis of the intermediate 5,7-difluoro-1H-indole To a solution of ethanol (35 mL) containing NaOEt (1.83 g, 26.9 mmol), a solution of ethyl (2,4-difluoro-6-trimethylsilylethynylphenyl)carbamate (2 g, 6.73 mmol) in ethanol (10 mL) was slowly added. The reaction mixture was stirred at room temperature for 1 h (monitored by TLC until the disappearance of the feedstock), followed by refluxing for 1 h. The reaction was completed by cooling to room temperature. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated under vacuum. The residue was dissolved in ether (50 mL) and washed sequentially with dilute hydrochloric acid (3 x 25 mL) and saturated saline (3 x 25 mL). The organic layer was dried with anhydrous Na2SO4, filtered and concentrated in vacuum. Purification by silica gel fast column chromatography (eluent ratio 1:4 ethyl acetate:hexane) gave 770 mg of the title compound in 75% yield.

References

[1] Patent: WO2005/12291, 2005, A1. Location in patent: Page/Page column 63

5,7-Difluoroindole Preparation Products And Raw materials

Raw materials

Preparation Products

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301856-25-7, 5,7-DifluoroindoleRelated Search:

Indole-3-butyric acid Indoline Indometacin Indole-3-acetic acid 5-FLUORO-4-IODO-1H-PYRROLO[2,3-B]PYRIDINE 3,6-Dichloro-4-methylpyridazine Methyl 7-azaindole-6-carboxylate methyl 6‐bromo‐2‐oxo‐2,3‐dihydro‐1h‐indole‐4‐carboxylate 4-AMINO-1-[(2,4-DIMETHOXYPHENYL)METHYL]PYRROLIDIN-2-ONE 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID 6-Chloro-5-fluoro-7-azaindole 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]- 7-Bromopyrido[3,2-d]pyrimidin-4(3H)-one [1-(trifluoromethyl)cyclopropyl]methanamine hydrochloride 5,6-dichloro-1H-Indole-3-carboxaldehyde 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

5,7-DIFLUOROINDOLE

5,7-difluoroinde

1H-Indole,5,7-difluoro-(9CI)

5,7-Difluoro-1H-Indole

1H-Indole, 5,7-difluoro-

SWF-101

SW-101

5,8-Difluoroindole

301856-25-7

30185-25-7

HALIDE

INDOLE

Indoles and derivatives

pharmacetical

Indoles