1-N-CBZ-3-PIPERIDONE
- Product Name
- 1-N-CBZ-3-PIPERIDONE
- CAS No.
- 61995-20-8
- Chemical Name
- 1-N-CBZ-3-PIPERIDONE
- Synonyms
- BENZYL 3-OXOPIPERIDINE-1-CARBOXYLATE;1-CBZ-3-PIPERIDONE;N-Cbz-3-Piperidone;1-CBZ-3-PIPERIDINONE;1-N-CBZ-3-PIPERIDONE;1-Benzyloxycarbonyl-3-piperidone, 97+%;3-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;1-Piperidinecarboxylic acid, 3-oxo-, phenylmethyl ester
- CBNumber
- CB5346172
- Molecular Formula
- C13H15NO3
- Formula Weight
- 233.26
- MOL File
- 61995-20-8.mol
1-N-CBZ-3-PIPERIDONE Property
- Boiling point:
- 384.1±42.0 °C(Predicted)
- Density
- 1.212
- storage temp.
- 2-8°C
- pka
- -1.76±0.20(Predicted)
- form
- Liquid
- Appearance
- Light yellow to yellow Liquid
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C13H15NO3/c15-12-7-4-8-14(9-12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6H,4,7-10H2
- InChIKey
- ALXLNFWWLXCXSK-UHFFFAOYSA-N
- SMILES
- N1(C(OCC2=CC=CC=C2)=O)CCCC(=O)C1
- CAS DataBase Reference
- 61995-20-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 23-26-37-60
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B194173
- Product name
- Benzyl3-Oxopiperidine-1-carboxylate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H56-1-LB
- Product name
- 1-Cbz-3-piperidone
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 070829
- Product name
- 1-N-Cbz-3-piperidone
- Purity
- 96%
- Packaging
- 5g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 4H56-1-LB
- Product name
- 1-Cbz-3-piperidone
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 17200
- Product name
- 1-Z-3-piperidone,96%
- Purity
- 96%
- Packaging
- 250MG
- Price
- $46.37
- Updated
- 2021/12/16
1-N-CBZ-3-PIPERIDONE Chemical Properties,Usage,Production
Uses
1-Benzyloxycarbonyl-3-piperidone finds its application in the synthesis and pharmacological evaluation of some 6-substituted 7-methyl-1,4-dioxa-7-azaspiro[4.5]decanes as potential dopamine agonists.
Synthesis
95798-22-4
61995-20-8
General procedure for the synthesis of 1-N-Cbz-3-piperidone from N-Benzyloxycarbonyl-3-hydroxypiperidine: N-Benzyloxycarbonyl-3-hydroxypiperidine (16.50 g, 70 mmol) was dissolved in dichloromethane (90 mL), stirred and cooled to 0 °C. Subsequently, N,N-diisopropylethylamine (DIPEA, 45.30 g, 0.35 mol) was added to the reaction system. A solution of dimethyl sulfoxide (DMSO, 100 mL) of pyridine trioxide (25.70 g, 0.16 mol) was slowly added dropwise at 0 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0°C for 2 hours. After completion of the reaction, the mixture was poured into 4 M hydrochloric acid and extracted with dichloromethane (100 mL x 3). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1/100 to 1/6, v/v) to afford 1-N-Cbz-3-piperidone (14.90 g, 90% yield) as an off-white solid. The structure of the product was confirmed by LC-MS, LC-MS: [M + H]+ = 234.
References
[1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 6, p. 1843 - 1845
[2] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 45
[3] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 6, p. 811 - 814
[4] Patent: EP1757582, 2007, A1. Location in patent: Page/Page column 35-36
[5] Patent: WO2014/68527, 2014, A1. Location in patent: Page/Page column 75; 156; 157
1-N-CBZ-3-PIPERIDONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-N-CBZ-3-PIPERIDONE manufacturers
- Product
- 1-N-CBZ-3-PIPERIDONE 61995-20-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 96%
- Supply Ability
- 500kg
- Release date
- 2018-08-20